Immunotherapy for colorectal cancer: where are we heading?

Debora Basile, Silvio Ken Garattini, Marta Bonotto, Elena Ongaro, Mariaelena Casagrande, Monica Cattaneo, Valentina Fanotto, Elisa De Carlo, Fotios Loupakis, Federica Urbano, Francesca V. Negri, Nicoletta Pella, Marco Russano, Oronzo Brunetti, Mario Scartozzi, Daniele Santini, Nicola Silvestris, Andrea Casadei Gardini, Marco Puzzoni, Lorenzo CalvettiNadia Cardarelli, Giuseppe Aprile

Research output: Contribution to journalReview article

Abstract

Introduction: In the last few years, significant advances in molecular biology have provided new therapeutic options for colorectal cancer (CRC). The development of new drugs that target the immune response to cancer cells seems very promising and has already been established for other tumor types. In particular, the use of immune checkpoint inhibitors seems to be an encouraging immunotherapeutic strategy. Areas covered: In this review, the authors provide an update of the current evidence related to this topic, though most immunotherapies are still in early-phase clinical trials for CRC. To understand the key role of immunotherapy in CRC, the authors discuss the delicate balance between immune-stimulating and immune-suppressive networks that occur in the tumor microenvironment. Expert opinion: Modulation of the immune system through checkpoint inhibition is an emerging approach in CRC therapy. Nevertheless, selection criteria that could enable the identification of patients who may benefit from these agents are necessary. Furthermore, potential prognostic and predictive immune biomarkers based on immune and molecular classifications have been proposed. As expected, additional studies are required to develop biomarkers, effective therapeutic strategies and novel combinations to overcome immune escape resistance and enhance effector response.

Original languageEnglish
Pages (from-to)709-721
Number of pages13
JournalExpert Opinion on Biological Therapy
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 3 2017

Keywords

  • atezolizumab
  • colorectal cancer
  • Immunotherapy
  • MSI
  • PD-L1
  • pembrolizumab

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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  • Cite this

    Basile, D., Garattini, S. K., Bonotto, M., Ongaro, E., Casagrande, M., Cattaneo, M., Fanotto, V., De Carlo, E., Loupakis, F., Urbano, F., Negri, F. V., Pella, N., Russano, M., Brunetti, O., Scartozzi, M., Santini, D., Silvestris, N., Casadei Gardini, A., Puzzoni, M., ... Aprile, G. (2017). Immunotherapy for colorectal cancer: where are we heading? Expert Opinion on Biological Therapy, 17(6), 709-721. https://doi.org/10.1080/14712598.2017.1315405