TY - JOUR
T1 - Immunotherapy in non-small-cell lung cancer
T2 - A bridge between research and clinical practice
AU - Francesco, Passiglia
AU - Oriana, Commendatore
AU - Milena, Vitali
AU - Raffaele, Conca
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Lung cancer has been historically considered a poorly immunogenic disease because of the few evidence of immune responses in affected patients and the limited efficacy of immunomodulating strategies. Recent understanding of the molecular mechanisms leading to cancer immune evasion has allowed the development of a new class of drugs called immune checkpoint inhibitors, which reactivate host responses with outstanding clinical benefits in a portion of patients with non-small-cell lung cancer. In this review, we briefly summarize the basis of immunogenicity and immune escape of cancer, with specific focus on non-small-cell lung cancer, mechanisms underlying immune checkpoint inhibitors efficacy and the most updated results on potential biomarkers, with the final aim of defining current unmet needs of immunotherapy in clinical practice.
AB - Lung cancer has been historically considered a poorly immunogenic disease because of the few evidence of immune responses in affected patients and the limited efficacy of immunomodulating strategies. Recent understanding of the molecular mechanisms leading to cancer immune evasion has allowed the development of a new class of drugs called immune checkpoint inhibitors, which reactivate host responses with outstanding clinical benefits in a portion of patients with non-small-cell lung cancer. In this review, we briefly summarize the basis of immunogenicity and immune escape of cancer, with specific focus on non-small-cell lung cancer, mechanisms underlying immune checkpoint inhibitors efficacy and the most updated results on potential biomarkers, with the final aim of defining current unmet needs of immunotherapy in clinical practice.
KW - biomarkers
KW - cancer immunogenicity
KW - clinical studies
KW - immune checkpoint inhibitors
KW - NSCLC
KW - PD-1
KW - PD-L1
KW - translational research
UR - http://www.scopus.com/inward/record.url?scp=85050010879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85050010879&partnerID=8YFLogxK
U2 - 10.2217/fon-2018-0098
DO - 10.2217/fon-2018-0098
M3 - Article
C2 - 29989452
AN - SCOPUS:85050010879
VL - 14
SP - 41
EP - 60
JO - Future Oncology
JF - Future Oncology
SN - 1479-6694
IS - 13s
ER -