Immunotherapy in non-small-cell lung cancer: Potential predictors of response and new strategies to assess activity

Research output: Contribution to journalReview article

Abstract

The treatment algorithm of advanced non-small-cell lung cancer is rapidly evolving. This result is mostly related to the availability in clinical practice of checkpoint inhibitors targeting the programmed death-1 (PD-1) and its ligands (PD-Ls) immunosuppressive pathway. Although patient's selection in the first-line setting relies essentially on high levels of PD-L1 tumor expression, treatment choice in pretreated patients is more challenging and, although clinical and biological characteristics might be of help, there is an urgent need for novel tools to better identify sensitive and resistant patients. In this context, the integration of molecular markers and immune-PET imaging might represent a potentially effective strategy to refine patient selection.

Original languageEnglish
Pages (from-to)797-805
Number of pages9
JournalImmunotherapy
Volume10
Issue number9
DOIs
Publication statusPublished - Jul 1 2018

    Fingerprint

Keywords

  • checkpoint inhibitors
  • FDG-PET
  • immune-PET
  • immune-related response criteria
  • irRECIST
  • NSCLC

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this