Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives

Jole Ventriglia, Immacolata Paciolla, Carmela Pisano, Sabrina Chiara Cecere, Marilena Di Napoli, Rosa Tambaro, Daniela Califano, Simona Losito, Giosuè Scognamiglio, Sergio Venanzio Setola, Laura Arenare, Sandro Pignata, Chiara Della Pepa

Research output: Contribution to journalReview article

Abstract

The tumors of the female genital tract represent a leading cause of morbidity and mortality among women worldwide. Substantial progresses have been made in ovarian cancer, with the increasing knowledge about BRCA mutated tumors and the recent development of PARP inhibitors, and in cervical cancer, thanks to extensive screening and widespread of vaccination against Human Papilloma Virus. Nevertheless many needs remain unmet, advanced stage diseases are still incurable and cervical and endometrial carcinoma, as well as platinum-resistant ovarian carcinoma, can certainly be classifiable among the cancers with poor sensitivity to conventional chemotherapy. Immunotherapy, including a number of approaches, checkpoint inhibitors, adoptive cellular transfer, vaccines, has experienced a remarkable growth in the last few years and it is already an available option in melanoma, lung and renal malignancies. We reviewed the main findings about the immune microenvironment in ovarian, endometrial and cervical cancer with a special focus on the clinical data, the therapeutic implications and the most promising novel agents.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalCancer Treatment Reviews
Volume59
DOIs
Publication statusPublished - Sep 1 2017

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Keywords

  • Cervical cancer
  • Endometrial cancer
  • Immunotherapy
  • Ovarian cancer
  • PD1/PD-L1

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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