Immunoterapia del melanoma e terapie adiuvanti

Biotherapies, including immunotherapy, are a field of great interest in the treatment of malignant melanoma and many new approaches have been proposed in the last years. The aim of this paper is to review the literature on immunotherapies (vaccines, cytokines, adjuvant immunotherapies) in the treatment of malignant melanoma. There is a wide diversity in contents and quality of studies. Frequently, the therapies are proposed for advanced disease as the "last chance" for the patients. Hopefully, quality of the studies could be improved by selecting a priori patients bearing a particular target with not heavily pretreated disease and by evaluating biological end-points.