Immunotherapy of metastatic kidney cancer

Giancarlo Pizza, Caterina De Vinci, Giuseppe Lo Conte, Paolo Maver, Ennio Dragoni, Ernesto Aiello, Vittorio Fornarola, Tiziano Bergami, Luciano Busutti, Stefano Boriani, Aldopaolo Palareti, Rodolfo Capanna

Research output: Contribution to journalArticlepeer-review

Abstract

From April 1986 to September 2000, 122 MRCC patients were treated by monthly intralymphatic injections (containing a mean of 573 IL-2 U and 26 × 106 LAK cells) and i.m. administration of IFN and TF; 71 patients also received a 3-day cycle of monthly IL-2 inhalations with a mean of 998 daily U. MRCC cases not treated by immunotherapy (n = 89) represent our historical controls. Adverse clinical side effects related to treatment were negligible. CR (n = 11) and PR (n = 13) were noticed in 24/122 patients. Of 24 responding patients, 17 resumed progression, whereas 7 remain in remission 11-69 months later. The overall median survival of treated patients (28 months) was 3.5-fold higher than the median survival of historical controls (7.5 months), and a Kaplan-Meier curve showed 25% survival 11 years after the beginning of immunotherapy. Apparently, the addition of IL-2 by inhalation improved survival. The present immunotherapy protocol appears to be efficacious, safe, devoid of adverse side effects, far less costly than others and able to offer a good quality of life to MRCC patients; if confirmed in a multicenter trial, it could set the basis for developing low-dose immunomodulatory treatments.

Original languageEnglish
Pages (from-to)109-120
Number of pages12
JournalInternational Journal of Cancer
Volume94
Issue number1
DOIs
Publication statusPublished - Oct 1 2001

Keywords

  • IL-2
  • Immunotherapy
  • Interferon
  • Lymphokine-activated killer cells
  • Metastasis
  • Renal cancer
  • Transfer factor

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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