IMMUNOTERAPIA CON IL-2 SOTTOCUTANEA RICOMBINANTE ED INTERFERONE ASSOCIATA A CHIRURGIA NEL CARCINOMA DEL RENE IN STADIO AVANZATO

Translated title of the contribution: Immunotherapy with subcutaneous rIL-2 and IFN plus surgery for advanced renal cell cancer

M. Maffezzini, A. Simonato, C. Lodolo, G. Carmignani

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Abstract

Twelve consecutive patients with metastatic renal cell carcinoma were submitted to an integrate treatment plan of immunotherapy with subcutaneous IL-2 and IFN and radical surgery in a pilot study. Partial response were observed in 2 patients, stable disease in 5 patients and progression of disease under treatment were observed in 5. Two RP were maintained for 12 and 18+ months and 1 SD is maintained at 12+ months. Treatment was well tolerated without significant toxicity. Integrated radical surgery and immunotherapy with s.c. IL-2 and IFN can produce occasionally protracted clinical responses.

Original languageItalian
Pages (from-to)139-141
Number of pages3
JournalArchivio italiano di urologia, nefrologia, andrologia : organo ufficiale dell"Associazione per la ricerca in urologia = Urological, nephrological, and andrological sciences
Volume66
Issue number3
Publication statusPublished - 1994

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Renal Cell Carcinoma
Immunotherapy
Interleukin-2
Disease Progression
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "IMMUNOTERAPIA CON IL-2 SOTTOCUTANEA RICOMBINANTE ED INTERFERONE ASSOCIATA A CHIRURGIA NEL CARCINOMA DEL RENE IN STADIO AVANZATO",
abstract = "Twelve consecutive patients with metastatic renal cell carcinoma were submitted to an integrate treatment plan of immunotherapy with subcutaneous IL-2 and IFN and radical surgery in a pilot study. Partial response were observed in 2 patients, stable disease in 5 patients and progression of disease under treatment were observed in 5. Two RP were maintained for 12 and 18+ months and 1 SD is maintained at 12+ months. Treatment was well tolerated without significant toxicity. Integrated radical surgery and immunotherapy with s.c. IL-2 and IFN can produce occasionally protracted clinical responses.",
keywords = "immunotherapy, interferon, interleukin 2, renal cell cancer",
author = "M. Maffezzini and A. Simonato and C. Lodolo and G. Carmignani",
year = "1994",
language = "Italian",
volume = "66",
pages = "139--141",
journal = "Archivio Italiano di Urologia Nefrologia Andrologia",
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T1 - IMMUNOTERAPIA CON IL-2 SOTTOCUTANEA RICOMBINANTE ED INTERFERONE ASSOCIATA A CHIRURGIA NEL CARCINOMA DEL RENE IN STADIO AVANZATO

AU - Maffezzini, M.

AU - Simonato, A.

AU - Lodolo, C.

AU - Carmignani, G.

PY - 1994

Y1 - 1994

N2 - Twelve consecutive patients with metastatic renal cell carcinoma were submitted to an integrate treatment plan of immunotherapy with subcutaneous IL-2 and IFN and radical surgery in a pilot study. Partial response were observed in 2 patients, stable disease in 5 patients and progression of disease under treatment were observed in 5. Two RP were maintained for 12 and 18+ months and 1 SD is maintained at 12+ months. Treatment was well tolerated without significant toxicity. Integrated radical surgery and immunotherapy with s.c. IL-2 and IFN can produce occasionally protracted clinical responses.

AB - Twelve consecutive patients with metastatic renal cell carcinoma were submitted to an integrate treatment plan of immunotherapy with subcutaneous IL-2 and IFN and radical surgery in a pilot study. Partial response were observed in 2 patients, stable disease in 5 patients and progression of disease under treatment were observed in 5. Two RP were maintained for 12 and 18+ months and 1 SD is maintained at 12+ months. Treatment was well tolerated without significant toxicity. Integrated radical surgery and immunotherapy with s.c. IL-2 and IFN can produce occasionally protracted clinical responses.

KW - immunotherapy

KW - interferon

KW - interleukin 2

KW - renal cell cancer

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