L'immunotossicologia nella medicina del lavoro e dell'ambiente

Prospettive, limiti e obiettivi di ricerca

Translated title of the contribution: Immunotoxicology in occupational and environmental health: Perspectives, restraints and aims of research

C. Colosio, W. Barcellini, E. Corsini

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The immune system is able to recognize and neutralize potentially harmful agents, conferring to the organism resistance to infections and malignant diseases. The authors have reviewed the literature and identified a group of substances able to enhance and/or reduce different immune functions, both in an experimental model and in occupational and environmental human exposure. The group includes several polyhalogenated hydrocarbons, particularly polychlorinated biphenyls, polybrominated biphenyls, tetrachloro-dibenzo-p-dioxin (TCDD), some metals like lead, cadmium and mercury, pesticides, i.e. dithiocarbamates and organotin compounds, organic solvents. The observed changes are usually slight and do not allow prognostic conclusion. In this study, the authors propose a 3-level rank of tests suitable for the immune evaluation of individuals occupationally exposed to xenobiotics, divided into three levels, as follows: tier 1: immunoglobulin classes (IgG, IgA, IgM), complement fractions (C3, C4), rheumatoid factor, and non-organ specific autoantibodies (AMA, SMA, ANA); CD3, CD4, CD8, CD57, CD20, HLA-DR; CD3/HLA-DR positive lymphocyte subsets; tier 2: determination of the mitotic response of peripheral blood lymphocytes to phytohaemoagglutinin, anti-CD3 monoclonal antibody, phorbol-myristate- acetate (PMA) and polyclonal immunoglobulin production after stimulation with pokeweed mitogen; tier 3: cytokine production with and without mitogen stimulation. The approach is 'step by step' and assumes the need of a closely integrated and comparative evaluation of the findings obtained. The protocol could be used in research fields; moreover, some of the tests could be useful in the monitoring of persons exposed in the environment or in the workplace to immunotoxic substances or to biological agents.

Original languageItalian
Pages (from-to)203-225
Number of pages23
JournalMedicina del Lavoro
Volume89
Issue number3
Publication statusPublished - 1998

Fingerprint

Environmental Health
HLA-DR Antigens
Occupational Health
Polybrominated Biphenyls
Organotin Compounds
Pokeweed Mitogens
Complement C3
Immunoglobulin Isotypes
Rheumatoid Factor
Polychlorinated Biphenyls
Lymphocyte Subsets
Environmental Exposure
Biological Factors
Phytohemagglutinins
Tetradecanoylphorbol Acetate
Xenobiotics
Hydrocarbons
Mercury
Cadmium
Mitogens

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

L'immunotossicologia nella medicina del lavoro e dell'ambiente : Prospettive, limiti e obiettivi di ricerca. / Colosio, C.; Barcellini, W.; Corsini, E.

In: Medicina del Lavoro, Vol. 89, No. 3, 1998, p. 203-225.

Research output: Contribution to journalArticle

@article{7f2d8224c92a4d708c7c5c1d0d3df3c6,
title = "L'immunotossicologia nella medicina del lavoro e dell'ambiente: Prospettive, limiti e obiettivi di ricerca",
abstract = "The immune system is able to recognize and neutralize potentially harmful agents, conferring to the organism resistance to infections and malignant diseases. The authors have reviewed the literature and identified a group of substances able to enhance and/or reduce different immune functions, both in an experimental model and in occupational and environmental human exposure. The group includes several polyhalogenated hydrocarbons, particularly polychlorinated biphenyls, polybrominated biphenyls, tetrachloro-dibenzo-p-dioxin (TCDD), some metals like lead, cadmium and mercury, pesticides, i.e. dithiocarbamates and organotin compounds, organic solvents. The observed changes are usually slight and do not allow prognostic conclusion. In this study, the authors propose a 3-level rank of tests suitable for the immune evaluation of individuals occupationally exposed to xenobiotics, divided into three levels, as follows: tier 1: immunoglobulin classes (IgG, IgA, IgM), complement fractions (C3, C4), rheumatoid factor, and non-organ specific autoantibodies (AMA, SMA, ANA); CD3, CD4, CD8, CD57, CD20, HLA-DR; CD3/HLA-DR positive lymphocyte subsets; tier 2: determination of the mitotic response of peripheral blood lymphocytes to phytohaemoagglutinin, anti-CD3 monoclonal antibody, phorbol-myristate- acetate (PMA) and polyclonal immunoglobulin production after stimulation with pokeweed mitogen; tier 3: cytokine production with and without mitogen stimulation. The approach is 'step by step' and assumes the need of a closely integrated and comparative evaluation of the findings obtained. The protocol could be used in research fields; moreover, some of the tests could be useful in the monitoring of persons exposed in the environment or in the workplace to immunotoxic substances or to biological agents.",
keywords = "Environmental exposure, Immunotoxicity, Occupational exposure",
author = "C. Colosio and W. Barcellini and E. Corsini",
year = "1998",
language = "Italian",
volume = "89",
pages = "203--225",
journal = "Medicina del Lavoro",
issn = "0025-7818",
publisher = "Mattioli 1885 S.p.A.",
number = "3",

}

TY - JOUR

T1 - L'immunotossicologia nella medicina del lavoro e dell'ambiente

T2 - Prospettive, limiti e obiettivi di ricerca

AU - Colosio, C.

AU - Barcellini, W.

AU - Corsini, E.

PY - 1998

Y1 - 1998

N2 - The immune system is able to recognize and neutralize potentially harmful agents, conferring to the organism resistance to infections and malignant diseases. The authors have reviewed the literature and identified a group of substances able to enhance and/or reduce different immune functions, both in an experimental model and in occupational and environmental human exposure. The group includes several polyhalogenated hydrocarbons, particularly polychlorinated biphenyls, polybrominated biphenyls, tetrachloro-dibenzo-p-dioxin (TCDD), some metals like lead, cadmium and mercury, pesticides, i.e. dithiocarbamates and organotin compounds, organic solvents. The observed changes are usually slight and do not allow prognostic conclusion. In this study, the authors propose a 3-level rank of tests suitable for the immune evaluation of individuals occupationally exposed to xenobiotics, divided into three levels, as follows: tier 1: immunoglobulin classes (IgG, IgA, IgM), complement fractions (C3, C4), rheumatoid factor, and non-organ specific autoantibodies (AMA, SMA, ANA); CD3, CD4, CD8, CD57, CD20, HLA-DR; CD3/HLA-DR positive lymphocyte subsets; tier 2: determination of the mitotic response of peripheral blood lymphocytes to phytohaemoagglutinin, anti-CD3 monoclonal antibody, phorbol-myristate- acetate (PMA) and polyclonal immunoglobulin production after stimulation with pokeweed mitogen; tier 3: cytokine production with and without mitogen stimulation. The approach is 'step by step' and assumes the need of a closely integrated and comparative evaluation of the findings obtained. The protocol could be used in research fields; moreover, some of the tests could be useful in the monitoring of persons exposed in the environment or in the workplace to immunotoxic substances or to biological agents.

AB - The immune system is able to recognize and neutralize potentially harmful agents, conferring to the organism resistance to infections and malignant diseases. The authors have reviewed the literature and identified a group of substances able to enhance and/or reduce different immune functions, both in an experimental model and in occupational and environmental human exposure. The group includes several polyhalogenated hydrocarbons, particularly polychlorinated biphenyls, polybrominated biphenyls, tetrachloro-dibenzo-p-dioxin (TCDD), some metals like lead, cadmium and mercury, pesticides, i.e. dithiocarbamates and organotin compounds, organic solvents. The observed changes are usually slight and do not allow prognostic conclusion. In this study, the authors propose a 3-level rank of tests suitable for the immune evaluation of individuals occupationally exposed to xenobiotics, divided into three levels, as follows: tier 1: immunoglobulin classes (IgG, IgA, IgM), complement fractions (C3, C4), rheumatoid factor, and non-organ specific autoantibodies (AMA, SMA, ANA); CD3, CD4, CD8, CD57, CD20, HLA-DR; CD3/HLA-DR positive lymphocyte subsets; tier 2: determination of the mitotic response of peripheral blood lymphocytes to phytohaemoagglutinin, anti-CD3 monoclonal antibody, phorbol-myristate- acetate (PMA) and polyclonal immunoglobulin production after stimulation with pokeweed mitogen; tier 3: cytokine production with and without mitogen stimulation. The approach is 'step by step' and assumes the need of a closely integrated and comparative evaluation of the findings obtained. The protocol could be used in research fields; moreover, some of the tests could be useful in the monitoring of persons exposed in the environment or in the workplace to immunotoxic substances or to biological agents.

KW - Environmental exposure

KW - Immunotoxicity

KW - Occupational exposure

UR - http://www.scopus.com/inward/record.url?scp=0031831844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031831844&partnerID=8YFLogxK

M3 - Articolo

VL - 89

SP - 203

EP - 225

JO - Medicina del Lavoro

JF - Medicina del Lavoro

SN - 0025-7818

IS - 3

ER -