Abstract
We isolated and treated in vitro with a novel CD5-specific saporin immunotoxin, referred to as OKT1-SAP, the cells infiltrating an irreversibly rejected renal allograft from a patient who rejected while on cyclosporine plus steroids and then failed to respond to multiple courses of high-dose steroids, intravenous OKT3 antibody, and local irradiation to the graft. We report here that under experimental conditions achievable in vivo the immunotoxin OKT1-SAP was capable of eliminating in vitro more than 95% of clonable T-lymphocytes infiltrating the rejected allograft of this patient despite their resistance to previous aggressive immunosuppression. To our knowledge, this is the first report of an immunotoxin-mediated suppression of the clonogenic growth of rejected renal allograft infiltrating T-lymphocytes.
Original language | English |
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Pages (from-to) | 84-88 |
Number of pages | 5 |
Journal | Journal of Biological Regulators and Homeostatic Agents |
Volume | 3 |
Issue number | 2 |
Publication status | Published - 1989 |
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Endocrinology
- Physiology
- Immunology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)