Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study

Nicola Latronico, Simone Piva, Nazzareno Fagoni, Lorenzo Pinelli, Michele Frigerio, Davide Tintori, Maurizio Berardino, Andrea Bottazzi, Livio Carnevale, Tiziana Casalicchio, Carlo Alberto Castioni, Simona Cavallo, Davide Cerasti, Giuseppe Citerio, Marco Fontanella, Serena Galiberti, Alan Girardini, Paolo Gritti, Ornella Manara, Paolo MaremmaniRoberta Mazzani, Giuseppe Natalini, Mirko Patassini, Maria Elena Perna, Ilaria Pesaresi, Danila Katia Radolovich, Maurizio Saini, Roberto Stefini, Cosetta Minelli, Roberto Gasparotti, Francesco A. Rasulo

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Post-traumatic cerebral infarction (PTCI) is common after traumatic brain injury (TBI). It is unclear what the occurrence of a PTCI is, how it impacts the long-term outcome, and whether it adds incremental prognostic value to established outcome predictors. METHODS: This was a prospective multicenter cohort study of moderate and severe TBI patients. The primary objective was to evaluate if PTCI was an independent risk factor for the 6-month outcome assessed with the Glasgow Outcome Scale (GOS). We also assessed the PTCI occurrence and if it adds incremental value to the International Mission for Prognosis and Clinical Trial design in TBI (IMPACT) core and extended models. RESULTS: We enrolled 143 patients, of whom 47 (32.9%) developed a PTCI. In the multiple ordered logistic regression, PTCI was retained in both the core and extended IMPACT models as an independent predictor of the GOS. The predictive performances increased significantly when PTCI was added to the IMPACT core model (AUC = 0.73, 95% C.I. 0.66-0.82; increased to AUC = 0.79, 95% CI 0.71-0.83, p = 0.0007) and extended model (AUC = 0.74, 95% C.I. 0.65-0.81 increased to AUC = 0.80, 95% C.I. 0.69-0.85; p = 0.00008). Patients with PTCI showed higher ICU mortality and 6-month mortality, whereas hospital mortality did not differ between the two groups. CONCLUSIONS: PTCI is a common complication in patients suffering from a moderate or severe TBI and is an independent risk factor for long-term disability. The addition of PTCI to the IMPACT core and extended predictive models significantly increased their performance in predicting the GOS. TRIAL REGISTRATION: The present study was registered in ClinicalTrial.gov with the ID number NCT02430324.

Original languageEnglish
Number of pages1
JournalCritical care (London, England)
Volume24
Issue number1
DOIs
Publication statusPublished - Feb 3 2020

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Keywords

  • Disability
  • Long term outcome
  • Posttraumatic cerebral infarction
  • Traumatic brain injury

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Latronico, N., Piva, S., Fagoni, N., Pinelli, L., Frigerio, M., Tintori, D., Berardino, M., Bottazzi, A., Carnevale, L., Casalicchio, T., Castioni, C. A., Cavallo, S., Cerasti, D., Citerio, G., Fontanella, M., Galiberti, S., Girardini, A., Gritti, P., Manara, O., ... Rasulo, F. A. (2020). Impact of a posttraumatic cerebral infarction on outcome in patients with TBI: the Italian multicenter cohort INCEPT study. Critical care (London, England), 24(1). https://doi.org/10.1186/s13054-020-2746-5