Impact of a treatment including tenofovir plus didanosine on the selection of the 65R mutation in highly drug-experienced HIV-infected patients

Nicola Gianotti, Elena Seminari, Giuliana Fusetti, Stefania Salpietro, Enzo Boeri, Andrea Galli, Adriano Lazzarin, Massimo Clementi, Antonella Castagna

Research output: Contribution to journalArticlepeer-review

Abstract

Data from 20 highly drug-experienced HIV-infected patients receiving tenofovir plus didanosine as part of a salvage regimen were analysed. At baseline, all but one patient harboured a virus bearing at least one nucleoside excision mutation (NEM); in 13 cases (65%) three or more NEM were detectable. After a median of 26 weeks of treatment, two patients (10%) selected the 65R mutation. These results support the hypothesis that NEM hinder the selection of this mutation.

Original languageEnglish
Pages (from-to)2205-2208
Number of pages4
JournalAIDS (London, England)
Volume18
Issue number16
DOIs
Publication statusPublished - Nov 5 2004

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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