TY - JOUR
T1 - Impact of acute and chronic stress on thrombosis in healthy individuals and cardiovascular disease patients
AU - Sandrini, Leonardo
AU - Ieraci, Alessandro
AU - Amadio, Patrizia
AU - Zarà, Marta
AU - Barbieri, Silvia Stella
N1 - Funding Information:
Funding: This work was supported by funding from the Italian Ministry of Health, Rome, Italy (Ricerca Corrente RC 2019 MPP 2B ID 2755316, RC 2020 MPP 2B ID 2757640, and 5 × 1000 2016–2018).
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Psychological stress induces different alterations in the organism in order to maintain homeostasis, including changes in hematopoiesis and hemostasis. In particular, stress-induced hyper activation of the autonomic nervous system and hypothalamic–pituitary–adrenal axis can trigger cellular and molecular alterations in platelets, coagulation factors, endothelial function, redox balance, and sterile inflammatory response. For this reason, mental stress is reported to enhance the risk of cardiovascular disease (CVD). However, contrasting results are often found in the literature considering differences in the response to acute or chronic stress and the health condition of the population analyzed. Since thrombosis is the most common underlying pathology of CVDs, the comprehension of the mechanisms at the basis of the association between stress and this pathology is highly valuable. The aim of this work is to give a comprehensive review of the studies focused on the role of acute and chronic stress in both healthy individuals and CVD patients, focusing on the cellular and molecular mechanisms underlying the relationship between stress and thrombosis.
AB - Psychological stress induces different alterations in the organism in order to maintain homeostasis, including changes in hematopoiesis and hemostasis. In particular, stress-induced hyper activation of the autonomic nervous system and hypothalamic–pituitary–adrenal axis can trigger cellular and molecular alterations in platelets, coagulation factors, endothelial function, redox balance, and sterile inflammatory response. For this reason, mental stress is reported to enhance the risk of cardiovascular disease (CVD). However, contrasting results are often found in the literature considering differences in the response to acute or chronic stress and the health condition of the population analyzed. Since thrombosis is the most common underlying pathology of CVDs, the comprehension of the mechanisms at the basis of the association between stress and this pathology is highly valuable. The aim of this work is to give a comprehensive review of the studies focused on the role of acute and chronic stress in both healthy individuals and CVD patients, focusing on the cellular and molecular mechanisms underlying the relationship between stress and thrombosis.
KW - Acute stress
KW - Chronic stress
KW - Coagulation
KW - Endothelial dysfunction
KW - Inflammation
KW - Platelets
KW - Psychological stress
KW - Thrombosis
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U2 - 10.3390/ijms21217818
DO - 10.3390/ijms21217818
M3 - Review article
C2 - 33105629
AN - SCOPUS:85094100181
VL - 21
SP - 1
EP - 26
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 21
M1 - 7818
ER -