Impact of acute hyperglycaemia on endothelial function and retinal vascular reactivity in patients with Type2 diabetes

M. V. Chittari, P. Mcternan, N. Bawazeer, K. Constantinides, M. Ciotola, J. P. O'Hare, S. Kumar, A. Ceriello

Research output: Contribution to journalArticle

Abstract

Aim In diabetes, endothelial dysfunction and an altered retinal blood flow have been reported and precede overt macrovascular and microvascular disease. Furthermore, an association between postprandial hyperglycaemia, retinopathy and cardiovascular disease has been observed. Methods Endothelial function and retinal vascular reactivity have been measured in baseline conditions in 10 healthy control subjects and 21 patients with Type2 diabetes. In the patients with Type2 diabetes, endothelial function and retinal vascular reactivity have been also measured every hour, for 4h, during an oral glucose tolerance test. Endothelial function has been evaluated by measuring flow-mediated vasodilation of the brachial artery, while retinal vascular reactivity has been measured using a retinal vessel analyser, during a flicker. Results At 1 and 2h after glucose ingestion, endothelial function decreased (P

Original languageEnglish
Pages (from-to)450-454
Number of pages5
JournalDiabetic Medicine
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 2011

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Keywords

  • Acute hyperglycaemia
  • Endothelial function
  • Retinal vasoreactivity

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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