Impact of acute-phase complications and interventions on 6-month survival after stroke. A prospective observational study

Antonio Di Carlo, Maria Lamassa, Marco Franceschini, Francesca Bovis, Lorenzo Cecconi, Sanaz Pournajaf, Stefano Paravati, Annibale Biggeri, Domenico Inzitari, Salvatore Ferro

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The outcome of stroke patients is complex and multidimensional. We evaluated the impact of acute-phase variables, including clinical state, complications, resource use and interventions, on 6-month survival after first-ever stroke, taking into account baseline conditions exerting a possible effect on outcome. As part of a National Research Program, we performed a prospective observational study of acute stroke patients in four Italian Regions. Consecutive patients admitted for a period of 3 months to the emergency rooms of participating hospitals were included. A total of 1030 patients were enrolled (median age 76.0 years, 52.1% males). At 6 months, 816 (79.2%) were alive, and 164 (15.9%) deceased. Survival status at the 6-month follow-up was missing for 50 (4.9%). Neurological state in the acute phase was significantly worse in patients deceased at 6 months, who showed also higher frequency of acute-phase complications. Cox regression analysis adjusted for demographics, pre-stroke function, baseline diseases and risk factors, indicated as significant predictors of 6-month death altered consciousness (HR, 1.70; 95% CI, 1.14–2.53), total anterior circulation infarct (HR, 2.13; 95% CI, 1.44–3.15), hyperthermia (HR, 1.70; 95% CI, 1.18–2.45), pneumonia (HR, 1.76; 95% CI, 1.18–2.61), heart failure (HR, 2.87; 95% CI, 1.34–6.13) and nasogastric feeding (HR, 2.35; 95% CI, 1.53–3.60), while antiplatelet therapy during acute phase (HR, 0.56; 95% CI, 0.39–0.79), and early mobilisation (HR, 0.55; 95% CI, 0.36–0.84) significantly increased 6-month survival. In a prospective observational study, stroke severity and some acute-phase complications, potentially modifiable, significantly increased the risk of 6-month death, independently of baseline variables. Early mobilisation positively affected survival, highlighting the role of early rehabilitation after stroke.

Original languageEnglish
Article numbere0194786
JournalPLoS One
Volume13
Issue number3
DOIs
Publication statusPublished - Mar 1 2018

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observational studies
stroke
Observational Studies
Emergency rooms
Stroke
Prospective Studies
Survival
Early Ambulation
Regression analysis
Patient rehabilitation
Acute-Phase Reaction
death
Consciousness
rehabilitation (people)
infarction
consciousness
enteral feeding
heart failure
Hospital Emergency Service
research programs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Impact of acute-phase complications and interventions on 6-month survival after stroke. A prospective observational study. / Carlo, Antonio Di; Lamassa, Maria; Franceschini, Marco; Bovis, Francesca; Cecconi, Lorenzo; Pournajaf, Sanaz; Paravati, Stefano; Biggeri, Annibale; Inzitari, Domenico; Ferro, Salvatore.

In: PLoS One, Vol. 13, No. 3, e0194786, 01.03.2018.

Research output: Contribution to journalArticle

Carlo, Antonio Di ; Lamassa, Maria ; Franceschini, Marco ; Bovis, Francesca ; Cecconi, Lorenzo ; Pournajaf, Sanaz ; Paravati, Stefano ; Biggeri, Annibale ; Inzitari, Domenico ; Ferro, Salvatore. / Impact of acute-phase complications and interventions on 6-month survival after stroke. A prospective observational study. In: PLoS One. 2018 ; Vol. 13, No. 3.
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