Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project

Julie K K Vishram; Anders Borglykke; Anne H. Andreasen; Jørgen Jeppesen; Hans Ibsen; Torben Jørgensen; Luigi Palmieri; Simona Giampaoli; Chiara Donfrancesco; Frank Kee; Giuseppe Mancia; Giancarlo Cesana; Kari Kuulasmaa; Veikko Salomaa; Susana Sans; Jean Ferrieres; Jean Dallongeville; Stefan Söderberg; Dominique Arveiler; Aline Wagner; Hugh Tunstall-Pedoe; Wojciech Drygas; Michael H. Olsen

doi:10.1371/journal.pone.0107294

Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project

Julie K K Vishram, Anders Borglykke, Anne H. Andreasen, Jørgen Jeppesen, Hans Ibsen, Torben Jørgensen, Luigi Palmieri, Simona Giampaoli, Chiara Donfrancesco, Frank Kee, Giuseppe Mancia, Giancarlo Cesana, Kari Kuulasmaa, Veikko Salomaa, Susana Sans, Jean Ferrieres, Jean Dallongeville, Stefan Söderberg, Dominique Arveiler, Aline WagnerHugh Tunstall-Pedoe, Wojciech Drygas, Michael H. Olsen

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS∗age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS∗age, P>0.05).

Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS).

Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19- 78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5.

Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.

Original language	English
Article number	e107294
Journal	PLoS One
Volume	9
Issue number	9
DOIs	https://doi.org/10.1371/journal.pone.0107294
Publication status	Published - Sep 22 2014

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

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Vishram, J. K. K., Borglykke, A., Andreasen, A. H., Jeppesen, J., Ibsen, H., Jørgensen, T., Palmieri, L., Giampaoli, S., Donfrancesco, C., Kee, F., Mancia, G., Cesana, G., Kuulasmaa, K., Salomaa, V., Sans, S., Ferrieres, J., Dallongeville, J., Söderberg, S., Arveiler, D., ... Olsen, M. H. (2014). Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project. PLoS One, 9(9), [e107294]. https://doi.org/10.1371/journal.pone.0107294

Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project. / Vishram, Julie K K; Borglykke, Anders; Andreasen, Anne H.; Jeppesen, Jørgen; Ibsen, Hans; Jørgensen, Torben; Palmieri, Luigi; Giampaoli, Simona; Donfrancesco, Chiara; Kee, Frank; Mancia, Giuseppe; Cesana, Giancarlo; Kuulasmaa, Kari; Salomaa, Veikko; Sans, Susana; Ferrieres, Jean; Dallongeville, Jean; Söderberg, Stefan; Arveiler, Dominique; Wagner, Aline; Tunstall-Pedoe, Hugh; Drygas, Wojciech; Olsen, Michael H.

In: PLoS One, Vol. 9, No. 9, e107294, 22.09.2014.

Research output: Contribution to journal › Article › peer-review

Vishram, JKK, Borglykke, A, Andreasen, AH, Jeppesen, J, Ibsen, H, Jørgensen, T, Palmieri, L, Giampaoli, S, Donfrancesco, C, Kee, F, Mancia, G, Cesana, G, Kuulasmaa, K, Salomaa, V, Sans, S, Ferrieres, J, Dallongeville, J, Söderberg, S, Arveiler, D, Wagner, A, Tunstall-Pedoe, H, Drygas, W & Olsen, MH 2014, 'Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project', PLoS One, vol. 9, no. 9, e107294. https://doi.org/10.1371/journal.pone.0107294

Vishram, Julie K K ; Borglykke, Anders ; Andreasen, Anne H. ; Jeppesen, Jørgen ; Ibsen, Hans ; Jørgensen, Torben ; Palmieri, Luigi ; Giampaoli, Simona ; Donfrancesco, Chiara ; Kee, Frank ; Mancia, Giuseppe ; Cesana, Giancarlo ; Kuulasmaa, Kari ; Salomaa, Veikko ; Sans, Susana ; Ferrieres, Jean ; Dallongeville, Jean ; Söderberg, Stefan ; Arveiler, Dominique ; Wagner, Aline ; Tunstall-Pedoe, Hugh ; Drygas, Wojciech ; Olsen, Michael H. / Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project. In: PLoS One. 2014 ; Vol. 9, No. 9.

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title = "Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project",

abstract = "Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS∗age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS∗age, P>0.05).Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS).Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19- 78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5.Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.",

author = "Vishram, {Julie K K} and Anders Borglykke and Andreasen, {Anne H.} and J{\o}rgen Jeppesen and Hans Ibsen and Torben J{\o}rgensen and Luigi Palmieri and Simona Giampaoli and Chiara Donfrancesco and Frank Kee and Giuseppe Mancia and Giancarlo Cesana and Kari Kuulasmaa and Veikko Salomaa and Susana Sans and Jean Ferrieres and Jean Dallongeville and Stefan S{\"o}derberg and Dominique Arveiler and Aline Wagner and Hugh Tunstall-Pedoe and Wojciech Drygas and Olsen, {Michael H.}",

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T1 - Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project

AU - Vishram, Julie K K

AU - Borglykke, Anders

AU - Andreasen, Anne H.

AU - Jeppesen, Jørgen

AU - Ibsen, Hans

AU - Jørgensen, Torben

AU - Palmieri, Luigi

AU - Giampaoli, Simona

AU - Donfrancesco, Chiara

AU - Kee, Frank

AU - Mancia, Giuseppe

AU - Cesana, Giancarlo

AU - Kuulasmaa, Kari

AU - Salomaa, Veikko

AU - Sans, Susana

AU - Ferrieres, Jean

AU - Dallongeville, Jean

AU - Söderberg, Stefan

AU - Arveiler, Dominique

AU - Wagner, Aline

AU - Tunstall-Pedoe, Hugh

AU - Drygas, Wojciech

AU - Olsen, Michael H.

PY - 2014/9/22

Y1 - 2014/9/22

N2 - Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS∗age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS∗age, P>0.05).Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS).Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19- 78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5.Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.

AB - Results: The prevalence of MetS, according to modified definitions of the International Diabetes Federation (IDF) and the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATPIII), increased across age groups for both genders (P0.05), in women the HRs for CHD declined with age (HRs 3.23/3.98 to 1.55/1.56; MetS∗age, P = 0.01/P = 0.001 for IDF/NCEP-ATPIII) while the HRs for stroke tended to increase (HRs 1.31/1.25 to 1.55/1.83; MetS∗age, P>0.05).Objective: To investigate the influence of age and gender on the prevalence and cardiovascular disease (CVD) risk in Europeans presenting with the Metabolic Syndrome (MetS).Methods: Using 36 cohorts from the MORGAM-Project with baseline between 1982-1997, 69094 men and women aged 19- 78 years, without known CVD, were included. During 12.2 years of follow-up, 3.7%/2.1% of men/women died due to CVD. The corresponding percentages for fatal and nonfatal coronary heart disease (CHD) and stroke were 8.3/3.8 and 3.1/2.5.Conclusion: In Europeans, both age and gender influenced the prevalence of MetS and its prognostic significance. The present results emphasise the importance of being critical of MetS in its current form as a marker of CVD especially in women, and advocate for a redefinition of MetS taking into account age especially in women.

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Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in europeans. the MORGAM prospective cohort project

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