Impact of age at diagnosis on overall and disease-free survival in men with prostate cancer following conformal 3D radiation therapy

Angelo Maggio, Rocco Panaia, Elisabetta Garibaldi, Sara Bresciani, Giuseppe Malinverni, Michele Stasi, Pietro Gabriele

Research output: Contribution to journalArticle

Abstract

Aims and background. The impact of age on prostate cancer outcome has been controversial. The aim of the study was to evaluate the role of age on overall survival and disease-free survival in patients affected by prostate cancer when treated with 3D conformal radiation therapy. Methods and study design. From 1999 to 2005, 1002 patients with T1-T3 prostate cancer were treated with 3D conformal radiation therapy, delivering a median dose of 75.6, 66.6 and 45 Gy to the prostate, seminal vesicles and pelvic nodes (if necessary), respectively. Patients were divided into four groups (75 years) according to age at diagnosis. The relationship between age and both overall survival and disease-free survival was calculated with Kaplan-Meier analysis and the comparison between curves was performed by the logrank test. ROC analysis allowed assessment of the best age cutoff. Results. Mean age was 71 ± 6 years (median, 72). Median and mean follow-up was 71.4 and 69 months, respectively. In multivariate analysis, there was no significant difference in the distribution of disease risk between age groups. Analysis demonstrated that older age is a strong positive predictor of survival (odds ratio for stratified patients older than 70 years was

Original languageEnglish
Pages (from-to)722-727
Number of pages6
JournalTumori
Volume98
Issue number6
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Age
  • Disease-free survival
  • Overall survival
  • Prostate cancer
  • Radiation therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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