Impact of age on postoperative outcomes in 1118 gastric cancer patients undergoing surgical treatment

Elena Orsenigo, Valentina Tomajer, Saverio Di Palo, Michele Carlucci, Andrea Vignali, Andrea Tamburini, Carlo Staudacher

Research output: Contribution to journalArticle

Abstract

Background. The purpose of the study was to evaluate the impact of age on outcomes in gastric cancer surgery. Methods. Patients on the hospital database who underwent gastric resection for gastric cancer during the period 1990-2005 (n = 1118) were divided into two groups: group A, patients 75 years or older (n = 249), and group B, those younger than 75 years (n = 869). Results. Overall preoperative complications were diagnosed in 92 (37%) patients of group A, compared with 147 (17%) in group B (P = 0.002). Fifty-five percent of patients underwent resection with D2 or more lymph node dissection (37% [n = 93] in group A, and 60% [n = 521] in group B; P = 0.003). Postoperative overall morbidity was higher in the elderly group (29% in group A versus 23% in group B), but the difference between the two groups was not significant (P = NS). Overall postoperative surgical complications were recorded in 201 (18%) patients; 49 (20%) in the elderly cohort, compared with 147 (17%) in the younger group (P = NS). The postoperative mortality rate was 3% (n = 7) in the elderly group, compared with 3% (n = 26) in the younger cohort (P = NS). Multivariate Cox analysis showed that age was not an independent risk factor for postoperative morbidity and mortality. Overall 5-year survival was 47% in group A and 54% in group B (P = NS). Conclusion. Due to improved perioperative management, resection of gastric carcinoma is the treatment of choice in elderly patients. Although comorbidities were more frequent among the elderly patients, postoperative morbidity and mortality, even after extensive resections, was low. Survival rates were comparable to those in the younger patients.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalGastric Cancer
Volume10
Issue number1
DOIs
Publication statusPublished - Feb 2007

Keywords

  • Elderly
  • Gastric cancer
  • Gastric resection

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

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    Orsenigo, E., Tomajer, V., Palo, S. D., Carlucci, M., Vignali, A., Tamburini, A., & Staudacher, C. (2007). Impact of age on postoperative outcomes in 1118 gastric cancer patients undergoing surgical treatment. Gastric Cancer, 10(1), 39-44. https://doi.org/10.1007/s10120-006-0409-0