Abstract
We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA match was assigned using imputation; concordance between HLA-match assignment and outcome correlation was confirmed between the actual and imputed HLA-match groups. Compared with HLA-matched units, neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 alleles.NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles compared with HLAmatched units. The observed effects are independent of cell dose and patient age. These data support allele-levelHLAmatching in the selection of single UCB units. (Blood. 2014;123(1):133-140).
| Original language | English |
|---|---|
| Pages (from-to) | 133-140 |
| Number of pages | 8 |
| Journal | Blood |
| Volume | 123 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2 2014 |
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ASJC Scopus subject areas
- Hematology
- Biochemistry
- Cell Biology
- Immunology
Cite this
Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy. / Eapen, Mary; Klein, John P.; Ruggeri, Annalisa; Spellman, Stephen; Lee, Stephanie J.; Anasetti, Claudio; Arcese, William; Barker, Juliet N.; Lee, Ann Baxter Lowe; Brown, Maria; Fernandez-Vina, Marcelo A.; Freeman, John; He, Wensheng; Iori, Anna Paola; Horowitz, Mary M.; Locatelli, Franco; Marino, Susana; Maiers, Martin; Michel, Gerard; Sanz, Guillermo F.; Gluckman, Eliane; Rocha, Vanderson.
In: Blood, Vol. 123, No. 1, 02.01.2014, p. 133-140.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of allele-level HLA matching on outcomes after myeloablative single unit umbilical cord blood transplantation for hematologic malignancy
AU - Eapen, Mary
AU - Klein, John P.
AU - Ruggeri, Annalisa
AU - Spellman, Stephen
AU - Lee, Stephanie J.
AU - Anasetti, Claudio
AU - Arcese, William
AU - Barker, Juliet N.
AU - Lee, Ann Baxter Lowe
AU - Brown, Maria
AU - Fernandez-Vina, Marcelo A.
AU - Freeman, John
AU - He, Wensheng
AU - Iori, Anna Paola
AU - Horowitz, Mary M.
AU - Locatelli, Franco
AU - Marino, Susana
AU - Maiers, Martin
AU - Michel, Gerard
AU - Sanz, Guillermo F.
AU - Gluckman, Eliane
AU - Rocha, Vanderson
PY - 2014/1/2
Y1 - 2014/1/2
N2 - We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA match was assigned using imputation; concordance between HLA-match assignment and outcome correlation was confirmed between the actual and imputed HLA-match groups. Compared with HLA-matched units, neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 alleles.NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles compared with HLAmatched units. The observed effects are independent of cell dose and patient age. These data support allele-levelHLAmatching in the selection of single UCB units. (Blood. 2014;123(1):133-140).
AB - We studied the effect of allele-level matching at human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 in 1568 single umbilical cord blood (UCB) transplantations for hematologic malignancy. The primary end point was nonrelapse mortality (NRM). Only 7% of units were allele matched at HLA-A, -B, -C, and -DRB1; 15% were mismatched at 1, 26% at 2, 30% at 3, 16% at 4, and 5% at 5 alleles. In a subset, allele-level HLA match was assigned using imputation; concordance between HLA-match assignment and outcome correlation was confirmed between the actual and imputed HLA-match groups. Compared with HLA-matched units, neutrophil recovery was lower with mismatches at 3, 4, or 5, but not 1 or 2 alleles.NRM was higher with units mismatched at 1, 2, 3, 4, or 5 alleles compared with HLAmatched units. The observed effects are independent of cell dose and patient age. These data support allele-levelHLAmatching in the selection of single UCB units. (Blood. 2014;123(1):133-140).
UR - http://www.scopus.com/inward/record.url?scp=84891778061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84891778061&partnerID=8YFLogxK
U2 - 10.1182/blood-2013-05-506253
DO - 10.1182/blood-2013-05-506253
M3 - Article
AN - SCOPUS:84891778061
VL - 123
SP - 133
EP - 140
JO - Blood
JF - Blood
SN - 0006-4971
IS - 1
ER -