IMMUNONUTRIZIONE ENTERALE PRECOCE NEL PAZIENTE ONCOLOGICO CHIRURGICO: VALUTAZIONE IMMUNOLOGICA E NUTRIZIONALE

Translated title of the contribution: Impact of an enriched enteral formula on immune function and nutritional status in cancer patients following surgery

A. Vignali, M. Braga, L. Gianotti, A. Cestari, M. Profili, T. Di Carlo

Research output: Contribution to journalArticle

Abstract

The aim of the study was to evaluate the effect of early administration of an enriched enteral formula on both immunological and nutritional status following curative surgery for gastric or pancreatic cancer. Forty-nine patients were randomized into 3 groups to receive either a standard enteral formula (n=16; Standard group), the same formula enriched with arginine, RNA and omega-3 fatty acids (n=16; Enriched group) or isonitrogen isocaloric parenteral nutrition (n=17; Parenteral group). Early enteral nutrition was starred within 12 hours following surgery. It was progressively increased, reaching a full regimen on day 4. Preoperatively and on postoperative days 1 and 8, the following nutritional parameters were evaluated: serum level of transferrin, albumin, prealbumin, retinol binding protein (RBP), cholinesterase. Delayed hypersensitivity response, IgG, IgM, IgA, lymphocyte subsets, monocyte phagocytosis ability were evaluated on admission and on postoperative days 1 and 8. In all groups a significant drop in nutritional and immunological parameter was observed on postoper ative day 1. Comparing postoperative day 1 versus day 8 a significant increase in prealbumin (p

Original languageItalian
Pages (from-to)25-31
Number of pages7
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Volume13
Issue number1
Publication statusPublished - 1995

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ASJC Scopus subject areas

  • Food Science
  • Anatomy
  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

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