TY - JOUR
T1 - IMMUNONUTRIZIONE ENTERALE PRECOCE NEL PAZIENTE ONCOLOGICO CHIRURGICO
T2 - VALUTAZIONE IMMUNOLOGICA E NUTRIZIONALE
AU - Vignali, A.
AU - Braga, M.
AU - Gianotti, L.
AU - Cestari, A.
AU - Profili, M.
AU - Di Carlo, T.
PY - 1995
Y1 - 1995
N2 - The aim of the study was to evaluate the effect of early administration of an enriched enteral formula on both immunological and nutritional status following curative surgery for gastric or pancreatic cancer. Forty-nine patients were randomized into 3 groups to receive either a standard enteral formula (n=16; Standard group), the same formula enriched with arginine, RNA and omega-3 fatty acids (n=16; Enriched group) or isonitrogen isocaloric parenteral nutrition (n=17; Parenteral group). Early enteral nutrition was starred within 12 hours following surgery. It was progressively increased, reaching a full regimen on day 4. Preoperatively and on postoperative days 1 and 8, the following nutritional parameters were evaluated: serum level of transferrin, albumin, prealbumin, retinol binding protein (RBP), cholinesterase. Delayed hypersensitivity response, IgG, IgM, IgA, lymphocyte subsets, monocyte phagocytosis ability were evaluated on admission and on postoperative days 1 and 8. In all groups a significant drop in nutritional and immunological parameter was observed on postoper ative day 1. Comparing postoperative day 1 versus day 8 a significant increase in prealbumin (p
AB - The aim of the study was to evaluate the effect of early administration of an enriched enteral formula on both immunological and nutritional status following curative surgery for gastric or pancreatic cancer. Forty-nine patients were randomized into 3 groups to receive either a standard enteral formula (n=16; Standard group), the same formula enriched with arginine, RNA and omega-3 fatty acids (n=16; Enriched group) or isonitrogen isocaloric parenteral nutrition (n=17; Parenteral group). Early enteral nutrition was starred within 12 hours following surgery. It was progressively increased, reaching a full regimen on day 4. Preoperatively and on postoperative days 1 and 8, the following nutritional parameters were evaluated: serum level of transferrin, albumin, prealbumin, retinol binding protein (RBP), cholinesterase. Delayed hypersensitivity response, IgG, IgM, IgA, lymphocyte subsets, monocyte phagocytosis ability were evaluated on admission and on postoperative days 1 and 8. In all groups a significant drop in nutritional and immunological parameter was observed on postoper ative day 1. Comparing postoperative day 1 versus day 8 a significant increase in prealbumin (p
KW - Early enteral feeding
KW - Immune function
KW - Nutritional status
KW - Oncological surgery
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M3 - Articolo
AN - SCOPUS:0028949906
VL - 13
SP - 25
EP - 31
JO - Rivista Italiana di Nutrizione Parenterale ed Enterale
JF - Rivista Italiana di Nutrizione Parenterale ed Enterale
SN - 0393-5582
IS - 1
ER -