Impact of antihypertensive combination and monotreatments on blood pressure variability: Assessment by old and new indices. Data from a large ambulatory blood pressure monitoring database

Gianfranco Parati, Eamon Dolan, Ludwin Ley, Helmut Schumacher

Research output: Contribution to journalArticle

Abstract

Objectives: High 24-h ambulatory blood pressure (ABP) variability is associated with poor cardiovascular outcomes. We analysed a large ABP monitoring database containing data from hypertensive patients treated with telmisartan/amlodipine combination or various monotherapies with the aim of quantifying the 24-h distribution of blood pressure (BP) reduction by treatment through the smoothness index and of developing and testing a new treatment-on-variability index (TOVI) to quantify the effects of treatment on both mean BP and BP variability. Methods: ABP data were pooled from 10 studies (N=4294) with a median follow-up of 60 days. Smoothness index was calculated by dividing the mean of treatment-induced hourly BP reductions by its SD. TOVI was calculated as the ratio of the mean of hourly BP reductions to weighted 24-h BP SD (weighted mean of daytime and night-time SDs) under treatment. Results: The SBP/DBP smoothness index and TOVI values of telmisartan/amlodipine combination were significantly (P

Original languageEnglish
Pages (from-to)1326-1333
Number of pages8
JournalJournal of Hypertension
Volume32
Issue number6
DOIs
Publication statusPublished - 2014

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Ambulatory Blood Pressure Monitoring
Antihypertensive Agents
Databases
Blood Pressure
Therapeutics

Keywords

  • antihypertensive treatment
  • blood pressure variability
  • hypertension
  • smoothness index

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

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title = "Impact of antihypertensive combination and monotreatments on blood pressure variability: Assessment by old and new indices. Data from a large ambulatory blood pressure monitoring database",
abstract = "Objectives: High 24-h ambulatory blood pressure (ABP) variability is associated with poor cardiovascular outcomes. We analysed a large ABP monitoring database containing data from hypertensive patients treated with telmisartan/amlodipine combination or various monotherapies with the aim of quantifying the 24-h distribution of blood pressure (BP) reduction by treatment through the smoothness index and of developing and testing a new treatment-on-variability index (TOVI) to quantify the effects of treatment on both mean BP and BP variability. Methods: ABP data were pooled from 10 studies (N=4294) with a median follow-up of 60 days. Smoothness index was calculated by dividing the mean of treatment-induced hourly BP reductions by its SD. TOVI was calculated as the ratio of the mean of hourly BP reductions to weighted 24-h BP SD (weighted mean of daytime and night-time SDs) under treatment. Results: The SBP/DBP smoothness index and TOVI values of telmisartan/amlodipine combination were significantly (P",
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author = "Gianfranco Parati and Eamon Dolan and Ludwin Ley and Helmut Schumacher",
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T2 - Assessment by old and new indices. Data from a large ambulatory blood pressure monitoring database

AU - Parati, Gianfranco

AU - Dolan, Eamon

AU - Ley, Ludwin

AU - Schumacher, Helmut

PY - 2014

Y1 - 2014

N2 - Objectives: High 24-h ambulatory blood pressure (ABP) variability is associated with poor cardiovascular outcomes. We analysed a large ABP monitoring database containing data from hypertensive patients treated with telmisartan/amlodipine combination or various monotherapies with the aim of quantifying the 24-h distribution of blood pressure (BP) reduction by treatment through the smoothness index and of developing and testing a new treatment-on-variability index (TOVI) to quantify the effects of treatment on both mean BP and BP variability. Methods: ABP data were pooled from 10 studies (N=4294) with a median follow-up of 60 days. Smoothness index was calculated by dividing the mean of treatment-induced hourly BP reductions by its SD. TOVI was calculated as the ratio of the mean of hourly BP reductions to weighted 24-h BP SD (weighted mean of daytime and night-time SDs) under treatment. Results: The SBP/DBP smoothness index and TOVI values of telmisartan/amlodipine combination were significantly (P

AB - Objectives: High 24-h ambulatory blood pressure (ABP) variability is associated with poor cardiovascular outcomes. We analysed a large ABP monitoring database containing data from hypertensive patients treated with telmisartan/amlodipine combination or various monotherapies with the aim of quantifying the 24-h distribution of blood pressure (BP) reduction by treatment through the smoothness index and of developing and testing a new treatment-on-variability index (TOVI) to quantify the effects of treatment on both mean BP and BP variability. Methods: ABP data were pooled from 10 studies (N=4294) with a median follow-up of 60 days. Smoothness index was calculated by dividing the mean of treatment-induced hourly BP reductions by its SD. TOVI was calculated as the ratio of the mean of hourly BP reductions to weighted 24-h BP SD (weighted mean of daytime and night-time SDs) under treatment. Results: The SBP/DBP smoothness index and TOVI values of telmisartan/amlodipine combination were significantly (P

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