Impact of Antiretroviral Therapy on the Risk of Recurrence in HIV-1 Infected Patients with Kaposi Sarcoma: A Multicenter Cohort Experience

Manuela Colafigli, Arturo Ciccullo, Alberto Borghetti, Iuri Fanti, Federico Melis, Sara Modica, Ilaria Uccella, Antonio Bonadies, Virginia Ferraresi, Enza Anzalone, Alfredo Pennica, Emilia Migliano, Barbara Rossetti, Giordano Madeddu, Roberto Cauda, Antonio Cristaudo, Simona Di Giambenedetto, Alessandra Latini

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Abstract

Kaposi sarcoma (KS) remains a relevant malignancy in human immunodeficiency virus (HIV)-infected patients with a non-standardized management; despite past suggestions that ritonavir-boosted protease inhibitor (bPI)-based regimens could be preferable, no combination antiretroviral therapy (cART) regimen was demonstrated to outperform the others and the impact of new drugs, drug classes or paradigms was never investigated nor proven better than previous therapeutic regimes. In order to do this, we retrospectively collected data regarding HIV-infected patients with a diagnosis of KS last seen in six Italian centers after 1 January 2013. A total of 104 KS cases in 99 patients was analyzed for 945.34 patient-year follow-up (PYFU). Twenty-six patients had visceral localizations. Thirty-three patients were treated with chemotherapy, four with electrochemotherapy, and 12 with α-interferon (α-IFN). At censor, 22% received a bPI-based, 14% a non-nucleoside reverse transcriptase inhibitor (NNRTI)-based, and 28% an integrase inhibitor (INI)-based standard cART, 24% a less drug regimen and 12% a mega-cART. Twelve recurrence episodes were observed in seven patients for an incidence of 1.27 per 100 PYFU. Two patients with no evidence of recurrence episodes died for other reasons. In our experience, KS recurrence episodes were infrequent. Despite the increasing use of new antiretroviral drug classes and new treatment paradigms, no excess of recurrence episodes was observed in patients receiving such cART regimens.

Original languageEnglish
JournalJournal of Clinical Medicine
Volume8
Issue number12
DOIs
Publication statusPublished - Nov 23 2019

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Colafigli, M., Ciccullo, A., Borghetti, A., Fanti, I., Melis, F., Modica, S., Uccella, I., Bonadies, A., Ferraresi, V., Anzalone, E., Pennica, A., Migliano, E., Rossetti, B., Madeddu, G., Cauda, R., Cristaudo, A., Di Giambenedetto, S., & Latini, A. (2019). Impact of Antiretroviral Therapy on the Risk of Recurrence in HIV-1 Infected Patients with Kaposi Sarcoma: A Multicenter Cohort Experience. Journal of Clinical Medicine, 8(12). https://doi.org/10.3390/jcm8122062