Impact of Aspirin on clinical outcome in advanced HCC patients receiving sorafenib and regorafenib

Andrea Casadei-Gardini, Giulia Rovesti, Vincenzo Dadduzio, Caterina Vivaldi, Eleonora Lai, Sara Lonardi, Lorenzo Fornaro, Andrea Pretta, Vittorina Zagonel, Laura Bernardini, Giorgio Astara, Francesco E D'Amico, Gianluca Masi, Margherita Rimini, Mario Scartozzi, Stefano Cascinu

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND AND AIM: The aim of our retrospective study is to evaluate the prognostic significance of aspirin in patients with advanced HCC treated with sorafenib.

METHODS: 304 patients with HCC,consecutively treated with sorafenib from May 2007 to September 2018, were included in the clinical study. Of Them 93 patients token aspirin. Progression-free survival (PFS)and overall survival (OS)were estimated with the Kaplan-Meier method and compared with the log-rank test.

RESULTS: The concomitant use of sorafenib and aspirin was associated with a median OS of 18.3 months compared to 8.8 months of patients who did not receive aspirin (HR 0.57; P < 0.0001). The concomitant use of sorafenib and aspirin was associated with a median PFS of 7.3 months compared to 3.0 months of patients who did not receive aspirin (HR 0.61; P = 0.0003). In the multivariate analysis, the use of aspirin maintained an independent prognostic value for OS(HR 0.61; P = 0.0013). In second line the concomitant use of regorafenib and aspirin was associated with a median OS of 16.9 months compared to 8.0 months of patients who did not receive aspirin (HR 0.30; P = 0.02).

CONCLUSION: Globally, our data seem to suggest that aspirin use may improve the clinical outcome of patients with advanced hepatocellular carcinoma receiving sorafenib and regorafenib.

Original languageEnglish
JournalHPB
DOIs
Publication statusE-pub ahead of print - Nov 12 2020

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