TY - JOUR
T1 - Impact of aspirin on takotsubo syndrome
T2 - a propensity score-based analysis of the InterTAK Registry
AU - InterTAK Registry
AU - D'Ascenzo, Fabrizio
AU - Gili, Sebastiano
AU - Bertaina, Maurizio
AU - Iannaccone, Mario
AU - Cammann, Victoria L
AU - Di Vece, Davide
AU - Kato, Ken
AU - Saglietto, Andrea
AU - Szawan, Konrad A
AU - Frangieh, Antonio H
AU - Boffini, Beatrice
AU - Annaratone, Margherita
AU - Sarcon, Annahita
AU - Levinson, Rena A
AU - Franke, Jennifer
AU - Napp, L Christian
AU - Jaguszewski, Milosz
AU - Noutsias, Michel
AU - Münzel, Thomas
AU - Knorr, Maike
AU - Heiner, Susanne
AU - Katus, Hugo A
AU - Burgdorf, Christof
AU - Schunkert, Heribert
AU - Thiele, Holger
AU - Bauersachs, Johann
AU - Tschöpe, Carsten
AU - Pieske, Burkert M
AU - Rajan, Lawrence
AU - Michels, Guido
AU - Pfister, Roman
AU - Cuneo, Alessandro
AU - Jacobshagen, Claudius
AU - Hasenfuß, Gerd
AU - Karakas, Mahir
AU - Koenig, Wolfgang
AU - Rottbauer, Wolfgang
AU - Said, Samir M
AU - Braun-Dullaeus, Ruediger C
AU - Banning, Adrian
AU - Cuculi, Florim
AU - Kobza, Richard
AU - Fischer, Thomas A
AU - Vasankari, Tuija
AU - Airaksinen, K E Juhani
AU - Opolski, Grzegorz
AU - Dworakowski, Rafal
AU - Crea, Filippo
AU - Biondi-Zoccai, Giuseppe
AU - De Ferrari, Gaetano Maria
N1 - © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology.
PY - 2019/12/20
Y1 - 2019/12/20
N2 - AIMS: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS).METHODS AND RESULTS: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting.CONCLUSION: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
AB - AIMS: The aim of the present study was to investigate the impact of aspirin on prognosis in takotsubo syndrome (TTS).METHODS AND RESULTS: Patients from the International Takotsubo (InterTAK) Registry were categorized into two groups based on aspirin prescription at discharge. A comparison of clinical outcomes between groups was performed using an adjusted analysis with propensity score (PS) stratification; results from the unadjusted analysis were also reported to note the effect of the PS adjustment. Major adverse cardiac and cerebrovascular events (MACCE: a composite of death, myocardial infarction, TTS recurrence, stroke or transient ischaemic attack) were assessed at 30-day and 5-year follow-up. A total of 1533 TTS patients with known status regarding aspirin prescription at discharge were included. According to the adjusted analysis based on PS stratification, aspirin was not associated with a lower hazard of MACCE at 30-day [hazard ratio (HR) 1.24, 95% confidence interval (CI) 0.50-3.04, P = 0.64] or 5-year follow-up (HR 1.11, 95% CI 0.78-1.58, P = 0.58). These results were confirmed by sensitivity analyses performed with alternative PS-based methods, i.e. covariate adjustment and inverse probability of treatment weighting.CONCLUSION: In the present study, no association was found between aspirin use in TTS patients and a reduced risk of MACCE at 30-day and 5-year follow-up. These findings should be confirmed in adequately powered randomized controlled trials. ClinicalTrials.gov Identifier: NCT01947621.
U2 - 10.1002/ejhf.1698
DO - 10.1002/ejhf.1698
M3 - Article
C2 - 31863563
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
ER -