Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents.

Tullio Palmerini, Antonio Marzocchi, Corrado Tamburino, Imad Sheiban, Massimo Margheri, Giuseppe Vecchi, Giuseppe Sangiorgi, Andrea Santarelli, Antonio Bartorelli, Carlo Briguori, Luigi Vignali, Francesco Di Pede, Angelo Ramondo, Luigi Inglese, Marco De Carlo, Giovanni Falsini, Alberto Benassi, Cataldo Palmieri, Vincenzo Filippone, Diego SangiorgiFabio Barlocco, Stefano De Servi

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

BACKGROUND: Distal unprotected left main coronary artery (ULMCA) stenosis represents a technical challenge for interventional cardiologists. In this study, we compared 2-year clinical outcomes of different stenting strategies in patients with distal ULMCA stenosis treated with drug-eluting stents. METHODS AND RESULTS: The survey promoted by the Italian Society of Invasive Cardiology on ULMCA stenosis was an observational study on patients with ULMCA stenosis treated with percutaneous coronary intervention. In this study, we selected patients with distal ULMCA stenosis treated with drug-eluting stents. Seven hundred seventy-three patients were eligible for this study: 456 were treated with 1 stent (group 1) and 317 with 2 stents (group 2). The primary end point of the study was the incidence of major adverse cardiac events (MACEs), defined as the occurrence of mortality, myocardial infarction, and target lesion revascularization. During a 2-year follow-up, risk-adjusted survival free from MACE was significantly higher in patients in group 1 than in patients in group 2. The propensity-adjusted hazard ratio for the risk of 2-year MACE in patients in group 1 versus group 2 was 0.53 (95% CI, 0.37 to 0.76). The propensity-adjusted hazard ratio for the risk of 2-year cardiac mortality and myocardial infarction in patients in group 1 versus group 2 was 0.38 (95% CI, 0.17 to 0.85). CONCLUSIONS: Compared with the 2-stent technique, the 1-stent technique is associated with a better 2-year MACE-free survival. The stenting strategy is a prognostic factor that should be taken into account when deciding the optimal revascularization treatment.

Original languageEnglish
Pages (from-to)185-192
Number of pages8
JournalCirculation: Cardiovascular Interventions
Volume1
Issue number3
Publication statusPublished - Dec 2008

Fingerprint

Drug-Eluting Stents
Coronary Stenosis
Stents
Odds Ratio
Myocardial Infarction
Mortality
Percutaneous Coronary Intervention
Cardiology
Disease-Free Survival
Observational Studies
Cohort Studies
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents. / Palmerini, Tullio; Marzocchi, Antonio; Tamburino, Corrado; Sheiban, Imad; Margheri, Massimo; Vecchi, Giuseppe; Sangiorgi, Giuseppe; Santarelli, Andrea; Bartorelli, Antonio; Briguori, Carlo; Vignali, Luigi; Di Pede, Francesco; Ramondo, Angelo; Inglese, Luigi; De Carlo, Marco; Falsini, Giovanni; Benassi, Alberto; Palmieri, Cataldo; Filippone, Vincenzo; Sangiorgi, Diego; Barlocco, Fabio; De Servi, Stefano.

In: Circulation: Cardiovascular Interventions, Vol. 1, No. 3, 12.2008, p. 185-192.

Research output: Contribution to journalArticle

Palmerini, T, Marzocchi, A, Tamburino, C, Sheiban, I, Margheri, M, Vecchi, G, Sangiorgi, G, Santarelli, A, Bartorelli, A, Briguori, C, Vignali, L, Di Pede, F, Ramondo, A, Inglese, L, De Carlo, M, Falsini, G, Benassi, A, Palmieri, C, Filippone, V, Sangiorgi, D, Barlocco, F & De Servi, S 2008, 'Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents.', Circulation: Cardiovascular Interventions, vol. 1, no. 3, pp. 185-192.
Palmerini, Tullio ; Marzocchi, Antonio ; Tamburino, Corrado ; Sheiban, Imad ; Margheri, Massimo ; Vecchi, Giuseppe ; Sangiorgi, Giuseppe ; Santarelli, Andrea ; Bartorelli, Antonio ; Briguori, Carlo ; Vignali, Luigi ; Di Pede, Francesco ; Ramondo, Angelo ; Inglese, Luigi ; De Carlo, Marco ; Falsini, Giovanni ; Benassi, Alberto ; Palmieri, Cataldo ; Filippone, Vincenzo ; Sangiorgi, Diego ; Barlocco, Fabio ; De Servi, Stefano. / Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents. In: Circulation: Cardiovascular Interventions. 2008 ; Vol. 1, No. 3. pp. 185-192.
@article{60b6b46ba7c84a669b8155448f41882c,
title = "Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents.",
abstract = "BACKGROUND: Distal unprotected left main coronary artery (ULMCA) stenosis represents a technical challenge for interventional cardiologists. In this study, we compared 2-year clinical outcomes of different stenting strategies in patients with distal ULMCA stenosis treated with drug-eluting stents. METHODS AND RESULTS: The survey promoted by the Italian Society of Invasive Cardiology on ULMCA stenosis was an observational study on patients with ULMCA stenosis treated with percutaneous coronary intervention. In this study, we selected patients with distal ULMCA stenosis treated with drug-eluting stents. Seven hundred seventy-three patients were eligible for this study: 456 were treated with 1 stent (group 1) and 317 with 2 stents (group 2). The primary end point of the study was the incidence of major adverse cardiac events (MACEs), defined as the occurrence of mortality, myocardial infarction, and target lesion revascularization. During a 2-year follow-up, risk-adjusted survival free from MACE was significantly higher in patients in group 1 than in patients in group 2. The propensity-adjusted hazard ratio for the risk of 2-year MACE in patients in group 1 versus group 2 was 0.53 (95{\%} CI, 0.37 to 0.76). The propensity-adjusted hazard ratio for the risk of 2-year cardiac mortality and myocardial infarction in patients in group 1 versus group 2 was 0.38 (95{\%} CI, 0.17 to 0.85). CONCLUSIONS: Compared with the 2-stent technique, the 1-stent technique is associated with a better 2-year MACE-free survival. The stenting strategy is a prognostic factor that should be taken into account when deciding the optimal revascularization treatment.",
author = "Tullio Palmerini and Antonio Marzocchi and Corrado Tamburino and Imad Sheiban and Massimo Margheri and Giuseppe Vecchi and Giuseppe Sangiorgi and Andrea Santarelli and Antonio Bartorelli and Carlo Briguori and Luigi Vignali and {Di Pede}, Francesco and Angelo Ramondo and Luigi Inglese and {De Carlo}, Marco and Giovanni Falsini and Alberto Benassi and Cataldo Palmieri and Vincenzo Filippone and Diego Sangiorgi and Fabio Barlocco and {De Servi}, Stefano",
year = "2008",
month = "12",
language = "English",
volume = "1",
pages = "185--192",
journal = "Circulation: Cardiovascular Interventions",
issn = "1941-7640",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Impact of bifurcation technique on 2-year clinical outcomes in 773 patients with distal unprotected left main coronary artery stenosis treated with drug-eluting stents.

AU - Palmerini, Tullio

AU - Marzocchi, Antonio

AU - Tamburino, Corrado

AU - Sheiban, Imad

AU - Margheri, Massimo

AU - Vecchi, Giuseppe

AU - Sangiorgi, Giuseppe

AU - Santarelli, Andrea

AU - Bartorelli, Antonio

AU - Briguori, Carlo

AU - Vignali, Luigi

AU - Di Pede, Francesco

AU - Ramondo, Angelo

AU - Inglese, Luigi

AU - De Carlo, Marco

AU - Falsini, Giovanni

AU - Benassi, Alberto

AU - Palmieri, Cataldo

AU - Filippone, Vincenzo

AU - Sangiorgi, Diego

AU - Barlocco, Fabio

AU - De Servi, Stefano

PY - 2008/12

Y1 - 2008/12

N2 - BACKGROUND: Distal unprotected left main coronary artery (ULMCA) stenosis represents a technical challenge for interventional cardiologists. In this study, we compared 2-year clinical outcomes of different stenting strategies in patients with distal ULMCA stenosis treated with drug-eluting stents. METHODS AND RESULTS: The survey promoted by the Italian Society of Invasive Cardiology on ULMCA stenosis was an observational study on patients with ULMCA stenosis treated with percutaneous coronary intervention. In this study, we selected patients with distal ULMCA stenosis treated with drug-eluting stents. Seven hundred seventy-three patients were eligible for this study: 456 were treated with 1 stent (group 1) and 317 with 2 stents (group 2). The primary end point of the study was the incidence of major adverse cardiac events (MACEs), defined as the occurrence of mortality, myocardial infarction, and target lesion revascularization. During a 2-year follow-up, risk-adjusted survival free from MACE was significantly higher in patients in group 1 than in patients in group 2. The propensity-adjusted hazard ratio for the risk of 2-year MACE in patients in group 1 versus group 2 was 0.53 (95% CI, 0.37 to 0.76). The propensity-adjusted hazard ratio for the risk of 2-year cardiac mortality and myocardial infarction in patients in group 1 versus group 2 was 0.38 (95% CI, 0.17 to 0.85). CONCLUSIONS: Compared with the 2-stent technique, the 1-stent technique is associated with a better 2-year MACE-free survival. The stenting strategy is a prognostic factor that should be taken into account when deciding the optimal revascularization treatment.

AB - BACKGROUND: Distal unprotected left main coronary artery (ULMCA) stenosis represents a technical challenge for interventional cardiologists. In this study, we compared 2-year clinical outcomes of different stenting strategies in patients with distal ULMCA stenosis treated with drug-eluting stents. METHODS AND RESULTS: The survey promoted by the Italian Society of Invasive Cardiology on ULMCA stenosis was an observational study on patients with ULMCA stenosis treated with percutaneous coronary intervention. In this study, we selected patients with distal ULMCA stenosis treated with drug-eluting stents. Seven hundred seventy-three patients were eligible for this study: 456 were treated with 1 stent (group 1) and 317 with 2 stents (group 2). The primary end point of the study was the incidence of major adverse cardiac events (MACEs), defined as the occurrence of mortality, myocardial infarction, and target lesion revascularization. During a 2-year follow-up, risk-adjusted survival free from MACE was significantly higher in patients in group 1 than in patients in group 2. The propensity-adjusted hazard ratio for the risk of 2-year MACE in patients in group 1 versus group 2 was 0.53 (95% CI, 0.37 to 0.76). The propensity-adjusted hazard ratio for the risk of 2-year cardiac mortality and myocardial infarction in patients in group 1 versus group 2 was 0.38 (95% CI, 0.17 to 0.85). CONCLUSIONS: Compared with the 2-stent technique, the 1-stent technique is associated with a better 2-year MACE-free survival. The stenting strategy is a prognostic factor that should be taken into account when deciding the optimal revascularization treatment.

UR - http://www.scopus.com/inward/record.url?scp=65749083725&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65749083725&partnerID=8YFLogxK

M3 - Article

C2 - 20031677

AN - SCOPUS:65749083725

VL - 1

SP - 185

EP - 192

JO - Circulation: Cardiovascular Interventions

JF - Circulation: Cardiovascular Interventions

SN - 1941-7640

IS - 3

ER -