Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus

Francesca Cesana, Cristina Giannattasio, Stefano Nava, Francesco Soriano, Gianmaria Brambilla, Matteo Baroni, Paolo Meani, Marisa Varrenti, Felice Paleari, Pierluigi Gamba, Rita Facchetti, Marta Alloni, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aims. Diabetes mellitus is characterized by structural and functional alterations of the large- and medium-size arteries. Whether blood glucose variability, i.e. the glycemic oscillations occurring during the 24-h period, represents a risk factor for vascular alterations additional to and independent on HbA1c in type 1 diabetes mellitus is still undefined. The present study was carried out with the aim at investigating the impact of different measures of blood glucose variability on arterial structure and function. We studied 17 non-complicated type 1 diabetic patients (11 males, six females) with an age of 40.8 ± 7.6 years (mean ± SD). In each patient, 24-h glucose profile was obtained by continuous glucose monitoring system and glucose variability was expressed as mean ± SD of 24-h blood glucose levels, mean amplitude of glycemic excursions and postprandial hyperglycemic spikes. Arterial structure and function was measured as carotid IMT and stiffness. Major findings. The different approaches to assessing blood glucose variability well correlated between and with HbA1c. Carotid IMT and stiffness showed significant correlations with age, blood pressure, heart rate and daily insulin intake but a non- significant correlation with blood glucose variability. Principal conclusion. Thus, in type 1 diabetes mellitus, measures of glycemic variability are useful in predicting both actual and long-lasting glycemic control. In absence of diabetes-related complications and of any intima-media thickness alterations, the major predictors of arterial distensibility are represented by traditional risk factors beside glycemic 24-h control.

Original languageEnglish
Pages (from-to)355-361
Number of pages7
JournalBlood Pressure
Volume22
Issue number6
DOIs
Publication statusPublished - Dec 2013

Fingerprint

Carotid Intima-Media Thickness
Type 1 Diabetes Mellitus
Carotid Arteries
Blood Glucose
Glucose
Diabetes Complications
Blood Vessels
Diabetes Mellitus
Arteries
Heart Rate
Insulin
Blood Pressure

Keywords

  • Arterial stiffness
  • Carotid artery distensibility
  • Diabetes mellitus
  • Glycemia
  • Intima media thickness
  • Variability

ASJC Scopus subject areas

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Cesana, F., Giannattasio, C., Nava, S., Soriano, F., Brambilla, G., Baroni, M., ... Mancia, G. (2013). Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus. Blood Pressure, 22(6), 355-361. https://doi.org/10.3109/08037051.2013.791413

Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus. / Cesana, Francesca; Giannattasio, Cristina; Nava, Stefano; Soriano, Francesco; Brambilla, Gianmaria; Baroni, Matteo; Meani, Paolo; Varrenti, Marisa; Paleari, Felice; Gamba, Pierluigi; Facchetti, Rita; Alloni, Marta; Grassi, Guido; Mancia, Giuseppe.

In: Blood Pressure, Vol. 22, No. 6, 12.2013, p. 355-361.

Research output: Contribution to journalArticle

Cesana, F, Giannattasio, C, Nava, S, Soriano, F, Brambilla, G, Baroni, M, Meani, P, Varrenti, M, Paleari, F, Gamba, P, Facchetti, R, Alloni, M, Grassi, G & Mancia, G 2013, 'Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus', Blood Pressure, vol. 22, no. 6, pp. 355-361. https://doi.org/10.3109/08037051.2013.791413
Cesana, Francesca ; Giannattasio, Cristina ; Nava, Stefano ; Soriano, Francesco ; Brambilla, Gianmaria ; Baroni, Matteo ; Meani, Paolo ; Varrenti, Marisa ; Paleari, Felice ; Gamba, Pierluigi ; Facchetti, Rita ; Alloni, Marta ; Grassi, Guido ; Mancia, Giuseppe. / Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus. In: Blood Pressure. 2013 ; Vol. 22, No. 6. pp. 355-361.
@article{c8691f51f087446d8b27e852a00e0e75,
title = "Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus",
abstract = "Aims. Diabetes mellitus is characterized by structural and functional alterations of the large- and medium-size arteries. Whether blood glucose variability, i.e. the glycemic oscillations occurring during the 24-h period, represents a risk factor for vascular alterations additional to and independent on HbA1c in type 1 diabetes mellitus is still undefined. The present study was carried out with the aim at investigating the impact of different measures of blood glucose variability on arterial structure and function. We studied 17 non-complicated type 1 diabetic patients (11 males, six females) with an age of 40.8 ± 7.6 years (mean ± SD). In each patient, 24-h glucose profile was obtained by continuous glucose monitoring system and glucose variability was expressed as mean ± SD of 24-h blood glucose levels, mean amplitude of glycemic excursions and postprandial hyperglycemic spikes. Arterial structure and function was measured as carotid IMT and stiffness. Major findings. The different approaches to assessing blood glucose variability well correlated between and with HbA1c. Carotid IMT and stiffness showed significant correlations with age, blood pressure, heart rate and daily insulin intake but a non- significant correlation with blood glucose variability. Principal conclusion. Thus, in type 1 diabetes mellitus, measures of glycemic variability are useful in predicting both actual and long-lasting glycemic control. In absence of diabetes-related complications and of any intima-media thickness alterations, the major predictors of arterial distensibility are represented by traditional risk factors beside glycemic 24-h control.",
keywords = "Arterial stiffness, Carotid artery distensibility, Diabetes mellitus, Glycemia, Intima media thickness, Variability",
author = "Francesca Cesana and Cristina Giannattasio and Stefano Nava and Francesco Soriano and Gianmaria Brambilla and Matteo Baroni and Paolo Meani and Marisa Varrenti and Felice Paleari and Pierluigi Gamba and Rita Facchetti and Marta Alloni and Guido Grassi and Giuseppe Mancia",
year = "2013",
month = "12",
doi = "10.3109/08037051.2013.791413",
language = "English",
volume = "22",
pages = "355--361",
journal = "Blood Pressure",
issn = "0803-7051",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - Impact of blood glucose variability on carotid artery intima media thickness and distensibility in type 1 diabetes mellitus

AU - Cesana, Francesca

AU - Giannattasio, Cristina

AU - Nava, Stefano

AU - Soriano, Francesco

AU - Brambilla, Gianmaria

AU - Baroni, Matteo

AU - Meani, Paolo

AU - Varrenti, Marisa

AU - Paleari, Felice

AU - Gamba, Pierluigi

AU - Facchetti, Rita

AU - Alloni, Marta

AU - Grassi, Guido

AU - Mancia, Giuseppe

PY - 2013/12

Y1 - 2013/12

N2 - Aims. Diabetes mellitus is characterized by structural and functional alterations of the large- and medium-size arteries. Whether blood glucose variability, i.e. the glycemic oscillations occurring during the 24-h period, represents a risk factor for vascular alterations additional to and independent on HbA1c in type 1 diabetes mellitus is still undefined. The present study was carried out with the aim at investigating the impact of different measures of blood glucose variability on arterial structure and function. We studied 17 non-complicated type 1 diabetic patients (11 males, six females) with an age of 40.8 ± 7.6 years (mean ± SD). In each patient, 24-h glucose profile was obtained by continuous glucose monitoring system and glucose variability was expressed as mean ± SD of 24-h blood glucose levels, mean amplitude of glycemic excursions and postprandial hyperglycemic spikes. Arterial structure and function was measured as carotid IMT and stiffness. Major findings. The different approaches to assessing blood glucose variability well correlated between and with HbA1c. Carotid IMT and stiffness showed significant correlations with age, blood pressure, heart rate and daily insulin intake but a non- significant correlation with blood glucose variability. Principal conclusion. Thus, in type 1 diabetes mellitus, measures of glycemic variability are useful in predicting both actual and long-lasting glycemic control. In absence of diabetes-related complications and of any intima-media thickness alterations, the major predictors of arterial distensibility are represented by traditional risk factors beside glycemic 24-h control.

AB - Aims. Diabetes mellitus is characterized by structural and functional alterations of the large- and medium-size arteries. Whether blood glucose variability, i.e. the glycemic oscillations occurring during the 24-h period, represents a risk factor for vascular alterations additional to and independent on HbA1c in type 1 diabetes mellitus is still undefined. The present study was carried out with the aim at investigating the impact of different measures of blood glucose variability on arterial structure and function. We studied 17 non-complicated type 1 diabetic patients (11 males, six females) with an age of 40.8 ± 7.6 years (mean ± SD). In each patient, 24-h glucose profile was obtained by continuous glucose monitoring system and glucose variability was expressed as mean ± SD of 24-h blood glucose levels, mean amplitude of glycemic excursions and postprandial hyperglycemic spikes. Arterial structure and function was measured as carotid IMT and stiffness. Major findings. The different approaches to assessing blood glucose variability well correlated between and with HbA1c. Carotid IMT and stiffness showed significant correlations with age, blood pressure, heart rate and daily insulin intake but a non- significant correlation with blood glucose variability. Principal conclusion. Thus, in type 1 diabetes mellitus, measures of glycemic variability are useful in predicting both actual and long-lasting glycemic control. In absence of diabetes-related complications and of any intima-media thickness alterations, the major predictors of arterial distensibility are represented by traditional risk factors beside glycemic 24-h control.

KW - Arterial stiffness

KW - Carotid artery distensibility

KW - Diabetes mellitus

KW - Glycemia

KW - Intima media thickness

KW - Variability

UR - http://www.scopus.com/inward/record.url?scp=84887865039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887865039&partnerID=8YFLogxK

U2 - 10.3109/08037051.2013.791413

DO - 10.3109/08037051.2013.791413

M3 - Article

C2 - 23862738

AN - SCOPUS:84887865039

VL - 22

SP - 355

EP - 361

JO - Blood Pressure

JF - Blood Pressure

SN - 0803-7051

IS - 6

ER -