Impact of body mass index and waist circumference on the long-term risk of diabetes mellitus, hypertension, and cardiac organ damage

Michele Bombelli, Rita Facchetti, Roberto Sega, Stefano Carugo, Danilo Fodri, Gianmaria Brambilla, Cristina Giannattasio, Guido Grassi, Giuseppe Mancia

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Obesity is associated with a higher risk of developing diabetes mellitus (DM), hypertension (HT), and left ventricular hypertrophy (LVH). The present study assessed in the general population the impact of body weight and visceral obesity on the development of alterations in glucose metabolism and cardiac structure, as well as of elevation in blood pressure. In 1412 subjects randomly selected and representative of the general population of Monza, we assessed twice (in 1990/1991 and 2000/2001) body mass index (BMI); waist circumference; office, home, and 24-hour ambulatory (24-hour) blood pressure, fasting glycemia, and left ventricular mass (echocardiography). New-onset high-risk conditions were DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH. The incidence of new-onset DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH increased progressively from the quintile with the lowest to the quintile with the highest BMI values. Adjusting for confounders, the risk of developing new-onset DM; impaired fasting glucose; office, home, and 24-hour HT; and LVH increased significantly for an increase of 1 kg/m 2 of BMI and 1 cm of waist circumference (respectively, 8.4% [P>0.01], 9.5% [P>0.0001], 4.2% [P>0.0001], 3.9% [P>0.001], 2.5% [P>0.05], and 5.1% [P>0.001] for BMI and 3.2% [P>0.001], 3.5% [P>0.0001], 1.8% [P>0.0001], 1.5% [P>0.0001], 1.4% [P>0.001], and 2.6% [P>0.0001]). These data provide evidence that an increase in BMI and waist circumference is associated with a linearly increased adjusted risk of developing conditions with high cardiovascular risk, such as DM, impaired fasting glucose, in-and out-of-office HT, and LVH.

Original languageEnglish
Pages (from-to)1029-1035
Number of pages7
JournalHypertension
Volume58
Issue number6
DOIs
Publication statusPublished - Dec 2011

Fingerprint

Waist Circumference
Left Ventricular Hypertrophy
Fasting
Diabetes Mellitus
Body Mass Index
Hypertension
Glucose
Blood Pressure
Abdominal Obesity
Population
Echocardiography
Obesity
Body Weight
Incidence

Keywords

  • Ambulatory blood pressure
  • Cardiovascular risk
  • Home blood pressure
  • Hypertension office blood pressure
  • Left ventricular hypertrophy
  • Obesity
  • Overweight

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Impact of body mass index and waist circumference on the long-term risk of diabetes mellitus, hypertension, and cardiac organ damage. / Bombelli, Michele; Facchetti, Rita; Sega, Roberto; Carugo, Stefano; Fodri, Danilo; Brambilla, Gianmaria; Giannattasio, Cristina; Grassi, Guido; Mancia, Giuseppe.

In: Hypertension, Vol. 58, No. 6, 12.2011, p. 1029-1035.

Research output: Contribution to journalArticle

Bombelli, M, Facchetti, R, Sega, R, Carugo, S, Fodri, D, Brambilla, G, Giannattasio, C, Grassi, G & Mancia, G 2011, 'Impact of body mass index and waist circumference on the long-term risk of diabetes mellitus, hypertension, and cardiac organ damage', Hypertension, vol. 58, no. 6, pp. 1029-1035. https://doi.org/10.1161/HYPERTENSIONAHA.111.175125
Bombelli, Michele ; Facchetti, Rita ; Sega, Roberto ; Carugo, Stefano ; Fodri, Danilo ; Brambilla, Gianmaria ; Giannattasio, Cristina ; Grassi, Guido ; Mancia, Giuseppe. / Impact of body mass index and waist circumference on the long-term risk of diabetes mellitus, hypertension, and cardiac organ damage. In: Hypertension. 2011 ; Vol. 58, No. 6. pp. 1029-1035.
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