Impact of breast cancer screening in a population with high spontaneous coverage with mammography

Giulia Capodaglio, Manuel Zorzi, Sandro Tognazzo, Alessandra Greco, Federica Michieletto, Chiara Fedato, Adriana Montaguti, Anna Turrin, Antonio Ferro, Sandro Cinquetti, Francesca Russo, Maria Chiara Corti, Massimo Rugge, Ugo Fedeli

Research output: Contribution to journalArticle

Abstract

METHODS: In Veneto, screening was introduced in different years between 1999 and 2009 across 21 local health units (LHUs), inviting asymptomatic women aged 50-69 years to undergo mammography biennially. We compared BC mortality for the 1995-2014 period of women aged 40-49 and 50-74 years who were resident in LHUs where screening programs started in 2003 (early LHUs) with women resident in LHUs where screening was introduced later (late LHUs). Poisson regression models were applied to incidence-based mortality (IBM), including only deaths from BC arising within the screening period.

RESULTS: In the prescreening period and until 2010, BC mortality rates in early and late LHUs were similar in both age groups. In the last study period (2010-2014), we observed a 10% decrease in overall BC mortality in early compared to late LHU, limited to women aged 50-74 years. IBM was reduced by 8% (95% CI 1%-16%) in the overall study period and by 16% (6%-25%) in 2010-2014.

CONCLUSIONS: In the Veneto region, screening programs were associated with a significant impact on BC-specific mortality; such effect appeared at least 8 years after screening implementation.

OBJECTIVE: The impact of organized screening programs on breast cancer (BC) mortality is unclear in an era of high spontaneous referral of women to mammography. The aim of this study was to analyze if the introduction of mammographic screening programs reduced BC mortality in the Veneto region, Italy, despite already widespread spontaneous access to mammography.

Original languageEnglish
Pages (from-to)258-265
Number of pages8
JournalTumori
Volume104
Issue number4
DOIs
Publication statusPublished - Aug 1 2018

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Mammography
Early Detection of Cancer
Breast Neoplasms
Mortality
Health
Population
Incidence
Italy
Referral and Consultation
Age Groups

Keywords

  • Breast cancer
  • mortality
  • screening

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Impact of breast cancer screening in a population with high spontaneous coverage with mammography. / Capodaglio, Giulia; Zorzi, Manuel; Tognazzo, Sandro; Greco, Alessandra; Michieletto, Federica; Fedato, Chiara; Montaguti, Adriana; Turrin, Anna; Ferro, Antonio; Cinquetti, Sandro; Russo, Francesca; Corti, Maria Chiara; Rugge, Massimo; Fedeli, Ugo.

In: Tumori, Vol. 104, No. 4, 01.08.2018, p. 258-265.

Research output: Contribution to journalArticle

Capodaglio, G, Zorzi, M, Tognazzo, S, Greco, A, Michieletto, F, Fedato, C, Montaguti, A, Turrin, A, Ferro, A, Cinquetti, S, Russo, F, Corti, MC, Rugge, M & Fedeli, U 2018, 'Impact of breast cancer screening in a population with high spontaneous coverage with mammography', Tumori, vol. 104, no. 4, pp. 258-265. https://doi.org/10.1177/0300891618792439
Capodaglio, Giulia ; Zorzi, Manuel ; Tognazzo, Sandro ; Greco, Alessandra ; Michieletto, Federica ; Fedato, Chiara ; Montaguti, Adriana ; Turrin, Anna ; Ferro, Antonio ; Cinquetti, Sandro ; Russo, Francesca ; Corti, Maria Chiara ; Rugge, Massimo ; Fedeli, Ugo. / Impact of breast cancer screening in a population with high spontaneous coverage with mammography. In: Tumori. 2018 ; Vol. 104, No. 4. pp. 258-265.
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AU - Capodaglio, Giulia

AU - Zorzi, Manuel

AU - Tognazzo, Sandro

AU - Greco, Alessandra

AU - Michieletto, Federica

AU - Fedato, Chiara

AU - Montaguti, Adriana

AU - Turrin, Anna

AU - Ferro, Antonio

AU - Cinquetti, Sandro

AU - Russo, Francesca

AU - Corti, Maria Chiara

AU - Rugge, Massimo

AU - Fedeli, Ugo

PY - 2018/8/1

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N2 - METHODS: In Veneto, screening was introduced in different years between 1999 and 2009 across 21 local health units (LHUs), inviting asymptomatic women aged 50-69 years to undergo mammography biennially. We compared BC mortality for the 1995-2014 period of women aged 40-49 and 50-74 years who were resident in LHUs where screening programs started in 2003 (early LHUs) with women resident in LHUs where screening was introduced later (late LHUs). Poisson regression models were applied to incidence-based mortality (IBM), including only deaths from BC arising within the screening period.RESULTS: In the prescreening period and until 2010, BC mortality rates in early and late LHUs were similar in both age groups. In the last study period (2010-2014), we observed a 10% decrease in overall BC mortality in early compared to late LHU, limited to women aged 50-74 years. IBM was reduced by 8% (95% CI 1%-16%) in the overall study period and by 16% (6%-25%) in 2010-2014.CONCLUSIONS: In the Veneto region, screening programs were associated with a significant impact on BC-specific mortality; such effect appeared at least 8 years after screening implementation.OBJECTIVE: The impact of organized screening programs on breast cancer (BC) mortality is unclear in an era of high spontaneous referral of women to mammography. The aim of this study was to analyze if the introduction of mammographic screening programs reduced BC mortality in the Veneto region, Italy, despite already widespread spontaneous access to mammography.

AB - METHODS: In Veneto, screening was introduced in different years between 1999 and 2009 across 21 local health units (LHUs), inviting asymptomatic women aged 50-69 years to undergo mammography biennially. We compared BC mortality for the 1995-2014 period of women aged 40-49 and 50-74 years who were resident in LHUs where screening programs started in 2003 (early LHUs) with women resident in LHUs where screening was introduced later (late LHUs). Poisson regression models were applied to incidence-based mortality (IBM), including only deaths from BC arising within the screening period.RESULTS: In the prescreening period and until 2010, BC mortality rates in early and late LHUs were similar in both age groups. In the last study period (2010-2014), we observed a 10% decrease in overall BC mortality in early compared to late LHU, limited to women aged 50-74 years. IBM was reduced by 8% (95% CI 1%-16%) in the overall study period and by 16% (6%-25%) in 2010-2014.CONCLUSIONS: In the Veneto region, screening programs were associated with a significant impact on BC-specific mortality; such effect appeared at least 8 years after screening implementation.OBJECTIVE: The impact of organized screening programs on breast cancer (BC) mortality is unclear in an era of high spontaneous referral of women to mammography. The aim of this study was to analyze if the introduction of mammographic screening programs reduced BC mortality in the Veneto region, Italy, despite already widespread spontaneous access to mammography.

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