Impact of Candida spp. isolation in the respiratory tract in patients with intensive care unit-acquired pneumonia

S. Terraneo, M. Ferrer, I. Martín-Loeches, M. Esperatti, M. Di Pasquale, V. Giunta, M. Rinaudo, F. de Rosa, G. Li Bassi, S. Centanni, A. Torres

Research output: Contribution to journalArticle

Abstract

In immunocompetent patients with nosocomial pneumonia, the relationship between Candida spp. isolation in respiratory samples and outcomes or association with other pathogens is controversial. We therefore compared the characteristics and outcomes of patients with intensive care unit-acquired pneumonia (ICUAP), with or without Candida spp. isolation in the respiratory tract. In this prospective non-interventional study, we assessed 385 consecutive immunocompetent patients with ICUAP, according to the presence or absence of Candida spp. in lower respiratory tract samples. Candida spp. was isolated in at least one sample in 82 (21%) patients. Patients with Candida spp. had higher severity scores and organ dysfunction at admission and at onset of pneumonia. In multivariate analysis, previous surgery, diabetes mellitus and higher Simplified Acute Physiology Score II at ICU admission independently predicted isolation of Candida spp. There were no significant differences in the rate of specific aetiological pathogens, the systemic inflammatory response, and length of stay between patients with and without Candida spp. Mortality was also similar, even adjusted for potential confounders in propensity-adjusted multivariate analyses (adjusted hazard ratio 1.08, 95% CI 0.57-2.05, p 0.80 for 28-day mortality and adjusted hazard ratio 1.38, 95% CI 0.81-2.35, p 0.24 for 90-day mortality). Antifungal therapy was more frequently prescribed in patients with Candida spp. in respiratory samples but did not influence outcomes. Candida spp. airway isolation in patients with ICUAP is associated with more initial disease severity but does not influence outcomes in these patients, regardless of the use or not of antifungal therapy.

Original languageEnglish
Pages (from-to)94.e1-94.e8
JournalClinical Microbiology and Infection
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Candida
Respiratory System
Intensive Care Units
Pneumonia
Mortality
Multivariate Analysis
Patient Isolation
Organ Dysfunction Scores
Length of Stay
Diabetes Mellitus
Therapeutics

Keywords

  • Candida isolation
  • Intensive care unit-acquired pneumonia
  • Nosocomial infection
  • Systemic inflammatory response
  • Ventilator-associated pneumonia

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Impact of Candida spp. isolation in the respiratory tract in patients with intensive care unit-acquired pneumonia. / Terraneo, S.; Ferrer, M.; Martín-Loeches, I.; Esperatti, M.; Di Pasquale, M.; Giunta, V.; Rinaudo, M.; de Rosa, F.; Li Bassi, G.; Centanni, S.; Torres, A.

In: Clinical Microbiology and Infection, Vol. 22, No. 1, 01.01.2016, p. 94.e1-94.e8.

Research output: Contribution to journalArticle

Terraneo, S, Ferrer, M, Martín-Loeches, I, Esperatti, M, Di Pasquale, M, Giunta, V, Rinaudo, M, de Rosa, F, Li Bassi, G, Centanni, S & Torres, A 2016, 'Impact of Candida spp. isolation in the respiratory tract in patients with intensive care unit-acquired pneumonia', Clinical Microbiology and Infection, vol. 22, no. 1, pp. 94.e1-94.e8. https://doi.org/10.1016/j.cmi.2015.09.002
Terraneo, S. ; Ferrer, M. ; Martín-Loeches, I. ; Esperatti, M. ; Di Pasquale, M. ; Giunta, V. ; Rinaudo, M. ; de Rosa, F. ; Li Bassi, G. ; Centanni, S. ; Torres, A. / Impact of Candida spp. isolation in the respiratory tract in patients with intensive care unit-acquired pneumonia. In: Clinical Microbiology and Infection. 2016 ; Vol. 22, No. 1. pp. 94.e1-94.e8.
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