Impact of Candidate Genetic Polymorphisms in Prostate Cancer: An Overview

S. Salvi, V. Conteduca, G. Gurioli, D. Calistri, V. Casadio, U. De Giorgi

Research output: Contribution to journalArticle

Abstract

In the last few years, the presence of single nucleotide polymorphisms (SNPs) has been investigated in many tumors as predictor of disease aggressiveness and clinical outcome. We searched for relevant articles from 1998 to 2015 about the impact of SNPs in prostate cancer. Particularly, in this article, we review the pathogenetic, prognostic and predictive significance of gene polymorphisms in prostate tumor, providing a brief overview of studies in which the possible role of genetic variants was investigated in clinical settings. Because conflicting results often emerge about the impact of gene polymorphisms in prostate cancer, further larger studies are warranted in order to introduce gene polymorphism into clinical practice as biomarkers.

Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalMolecular Diagnosis and Therapy
Volume20
Issue number1
DOIs
Publication statusPublished - Feb 1 2016

Fingerprint

Genetic Polymorphisms
Prostatic Neoplasms
Single Nucleotide Polymorphism
Genes
Prostate
Neoplasms
Biomarkers

ASJC Scopus subject areas

  • Genetics
  • Molecular Medicine
  • Medicine(all)
  • Pharmacology

Cite this

Impact of Candidate Genetic Polymorphisms in Prostate Cancer : An Overview. / Salvi, S.; Conteduca, V.; Gurioli, G.; Calistri, D.; Casadio, V.; De Giorgi, U.

In: Molecular Diagnosis and Therapy, Vol. 20, No. 1, 01.02.2016, p. 1-12.

Research output: Contribution to journalArticle

@article{9738c0e11d2e408a88786b39457d6a8a,
title = "Impact of Candidate Genetic Polymorphisms in Prostate Cancer: An Overview",
abstract = "In the last few years, the presence of single nucleotide polymorphisms (SNPs) has been investigated in many tumors as predictor of disease aggressiveness and clinical outcome. We searched for relevant articles from 1998 to 2015 about the impact of SNPs in prostate cancer. Particularly, in this article, we review the pathogenetic, prognostic and predictive significance of gene polymorphisms in prostate tumor, providing a brief overview of studies in which the possible role of genetic variants was investigated in clinical settings. Because conflicting results often emerge about the impact of gene polymorphisms in prostate cancer, further larger studies are warranted in order to introduce gene polymorphism into clinical practice as biomarkers.",
author = "S. Salvi and V. Conteduca and G. Gurioli and D. Calistri and V. Casadio and {De Giorgi}, U.",
year = "2016",
month = "2",
day = "1",
doi = "10.1007/s40291-015-0169-9",
language = "English",
volume = "20",
pages = "1--12",
journal = "Molecular Diagnosis and Therapy",
issn = "1177-1062",
publisher = "Adis International Ltd",
number = "1",

}

TY - JOUR

T1 - Impact of Candidate Genetic Polymorphisms in Prostate Cancer

T2 - An Overview

AU - Salvi, S.

AU - Conteduca, V.

AU - Gurioli, G.

AU - Calistri, D.

AU - Casadio, V.

AU - De Giorgi, U.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - In the last few years, the presence of single nucleotide polymorphisms (SNPs) has been investigated in many tumors as predictor of disease aggressiveness and clinical outcome. We searched for relevant articles from 1998 to 2015 about the impact of SNPs in prostate cancer. Particularly, in this article, we review the pathogenetic, prognostic and predictive significance of gene polymorphisms in prostate tumor, providing a brief overview of studies in which the possible role of genetic variants was investigated in clinical settings. Because conflicting results often emerge about the impact of gene polymorphisms in prostate cancer, further larger studies are warranted in order to introduce gene polymorphism into clinical practice as biomarkers.

AB - In the last few years, the presence of single nucleotide polymorphisms (SNPs) has been investigated in many tumors as predictor of disease aggressiveness and clinical outcome. We searched for relevant articles from 1998 to 2015 about the impact of SNPs in prostate cancer. Particularly, in this article, we review the pathogenetic, prognostic and predictive significance of gene polymorphisms in prostate tumor, providing a brief overview of studies in which the possible role of genetic variants was investigated in clinical settings. Because conflicting results often emerge about the impact of gene polymorphisms in prostate cancer, further larger studies are warranted in order to introduce gene polymorphism into clinical practice as biomarkers.

UR - http://www.scopus.com/inward/record.url?scp=84956694666&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956694666&partnerID=8YFLogxK

U2 - 10.1007/s40291-015-0169-9

DO - 10.1007/s40291-015-0169-9

M3 - Article

AN - SCOPUS:84956694666

VL - 20

SP - 1

EP - 12

JO - Molecular Diagnosis and Therapy

JF - Molecular Diagnosis and Therapy

SN - 1177-1062

IS - 1

ER -