Impact of cardiac resynchronization therapy on the severity of mitral regurgitation

Luigi Di Biase, Angelo Auricchio, Prasant Mohanty, Rong Bai, Josef Kautzner, Paolo Pieragnoli, Francois Regoli, Antonio Sorgente, Giulio Spinucci, Giuseppe Ricciardi, Antonio Michelucci, Laura Perrotta, Francesco Faletra, Hancha Mlcochová, Kamil Sedlacek, Robert Canby, Javier E. Sanchez, Rodney Horton, J. David Burkhardt, Tiziano MoccettiLuigi Padeletti, Andrea Natale

Research output: Contribution to journalArticlepeer-review


Aims Functional mitral regurgitation (MR) could be managed by both cardiac resynchronization therapy (CRT) and mitral-valve surgery. Clinical decision making regarding the appropriateness of mitral-valve surgery vs. CRT is a challenging task. This study assessed the prevalence and prognosis of various degrees of functional MR in CRT candidates. Additionally, we sought to identify functional MR patients who either can be adequately managed by CRT only or will need surgery. Methods and results Cardiac resynchronization therapy recipients (n 794) were followed-up for 26 ± 18 months. Mitral regurgitation severity was quantified on scale 04. Cardiac resynchronization therapy responders were identified based on improvement in the New York Heart Association class and left-ventricular ejection fraction. Severity of MR and LV reverse remodelling were assessed at 3 and 12 months. Predictors of long-term MR change and CRT response were explored with multivariable models. Mitral regurgitation was present in 86, with 35 prevalence of advanced MR (grade 34). Improvement of MR

Original languageEnglish
Pages (from-to)829-838
Number of pages10
Issue number6
Publication statusPublished - Jun 2011


  • Cardiomyopathy
  • Heart failure
  • Mitral regurgitation
  • Pacing
  • Resynchronization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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