Impact of carotid stent cell design on vessel scaffolding: A case study comparing experimental investigation and numerical simulations

Michele Conti, Denis Van Loo, Ferdinando Auricchio, Matthieu De Beule, Gianluca De Santis, Benedict Verhegghe, Stefano Pirrelli, Attilio Odero

Research output: Contribution to journalArticle


Purpose: To quantitatively evaluate the impact of carotid stent cell design on vessel scaffolding by using patient-specific finite element analysis of carotid artery stenting (CAS). Methods: The study was organized in 2 parts: (1) validation of a patient-specific finite element analysis of CAS and (2) evaluation of vessel scaffolding. Micro-computed tomography (CT) images of an open-cell stent deployed in a patient-specific silicone mock artery were compared with the corresponding finite element analysis results. This simulation was repeated for the closed-cell counterpart. In the second part, the stent strut distribution, as reflected by the inter-strut angles, was evaluated for both cell types in different vessel cross sections as a measure of scaffolding. Results: The results of the patient-specific finite element analysis of CAS matched well with experimental stent deployment both qualitatively and quantitatively, demonstrating the reliability of the numerical approach. The measured inter-strut angles suggested that the closed-cell design provided superior vessel scaffolding compared to the open-cell counterpart. However, the full strut interconnection of the closed-cell design reduced the stent's ability to accommodate to the irregular eccentric profile of the vessel cross section, leading to a gap between the stent surface and the vessel wall. Conclusion: Even though this study was limited to a single stent design and one vascular anatomy, the study confirmed the capability of dedicated computer simulations to predict differences in scaffolding by open- and closed-cell carotid artery stents. These simulations have the potential to be used in the design of novel carotid stents or for procedure planning.

Original languageEnglish
Pages (from-to)397-406
Number of pages10
JournalJournal of Endovascular Therapy
Issue number3
Publication statusPublished - Jun 2011



  • Carotid artery
  • Cell design
  • Finite element analysis
  • Stent
  • Vessel scaffolding

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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