Impact of child obesity on adipose tissue physiology: Assessment of adipocytokines and inflammatory cytokines as biomarkers of obesity

Maria Chiara Leoni, Chiara Valsecchi, Melissa Mantelli, Laura Marastoni, Carmine Tinelli, Antonietta Marchi, Annamaria Castellazzi

Research output: Contribution to journalArticle

Abstract

Obesity could be interpreted as a low grade inflammatory state. The role of cytokines for innate and acquired immune response and adipocytokines in pathogenesis of obesity is not completely understood. The aim of the study was to evaluate anthropometric parameters, adipocytokines and inflammatory cytokine levels as biomarkers of childhood obesity. This investigation was designed as a longitudinal observational study. Forty-seven obese children (19 males and 28 females) were enrolled by Pediatric Clinic of the Foundation IRCCS Policlinico San Matteo, Pavia, Italy. For each patients a blood sample, used for other biochemical evaluations, was collected. Cytokines and adipocytokines plasmatic levels were determined using an ELISA method. Plasma leptin levels are in correlation with age (r=0.5; P

Original languageEnglish
Pages (from-to)62-66
Number of pages5
JournalPediatric Reports
Volume2
Issue number2
DOIs
Publication statusPublished - 2010

Keywords

  • Adipocytokines
  • BMI z-score
  • Inflammatory cytokines
  • Obesity

ASJC Scopus subject areas

  • Pediatrics

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