Impact of Clinical Presentation (Stable Angina Pectoris vs Unstable Angina Pectoris or Non-ST-Elevation Myocardial Infarction vs ST-Elevation Myocardial Infarction) on Long-Term Outcomes in Women Undergoing Percutaneous Coronary Intervention With Drug-Eluting Stents

Gennaro Giustino, Usman Baber, Giulio Giuseppe Stefanini, Melissa Aquino, Gregg W. Stone, Samantha Sartori, Philippe Gabriel Steg, William Wijns, Pieter C. Smits, Raban V. Jeger, Martin B. Leon, Stephan Windecker, Patrick W. Serruys, Marie Claude Morice, Edoardo Camenzind, Giora Weisz, David Kandzari, George D. Dangas, Ioannis Mastoris, Clemens Von BirgelenSoren Galatius, Takeshi Kimura, Ghada Mikhail, Dipti Itchhaporia, Laxmi Mehta, Rebecca Ortega, Hyo Soo Kim, Marco Valgimigli, Adnan Kastrati, Alaide Chieffo, Roxana Mehran

Research output: Contribution to journalArticlepeer-review

Abstract

The long-term risk associated with different coronary artery disease (CAD) presentations in women undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES) is poorly characterized. We pooled patient-level data for women enrolled in 26 randomized clinical trials. Of 11,577 women included in the pooled database, 10,133 with known clinical presentation received a DES. Of them, 5,760 (57%) had stable angina pectoris (SAP), 3,594 (35%) had unstable angina pectoris (UAP) or non-ST-segment-elevation myocardial infarction (NSTEMI), and 779 (8%) had ST-segment-elevation myocardial infarction (STEMI) as clinical presentation. A stepwise increase in 3-year crude cumulative mortality was observed in the transition from SAP to STEMI (4.9% vs 6.1% vs 9.4%; p interaction = 0.66). In conclusion, in women across the clinical spectrum of CAD, STEMI was associated with a greater risk of long-term mortality. Conversely, the adjusted risk of mortality between UAP or NSTEMI and SAP was similar. New-generation DESs provide improved long-term clinical outcomes irrespective of the clinical presentation in women.

Original languageEnglish
Article number21236
Pages (from-to)845-852
Number of pages8
JournalThe American Journal of Cardiology
Volume116
Issue number6
DOIs
Publication statusPublished - Sep 15 2015

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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