Impact of combined hormonal contraceptives on vessels functionality

Alessandro Rabiolo, Federico Corvi, Davide Monteduro, Lucia Benatti, Maria Vittoria Cicinelli, Giovanni Fogliato, Giuseppe Querques, Francesco Bandello

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the dynamic and static retinal vascular functionality in young females using combined hormonal contraceptive (CHC). Methods: Thirty-eight consecutive young female subjects were enrolled in this study between January 2015 and December 2015. Subjects were divided in two groups: CHC group, defined as CHC use for ≥6 months, and control group, defined as no current and prior CHC use. Participants underwent a dynamic and static retinal vessel analysis using the Dynamic Vessel Analyzer (DVA, Imedos, Jena, Germany). Results: Seventeen subjects continuously took CHC for 54.6 ± 29.3 months, while 21 subjects belonged to control group. No difference was found between the CHC and control groups for age (p = 0.1), smoking status (p = 0.6), and systolic (p = 0.3) and diastolic (p = 0.1) blood pressure. With regard to dynamic analysis, women taking CHC exhibited a marked significant vasoconstriction following flicker stimulation in comparison with control group (−2.43 ± 2.5 vs 0.63 ± 2.1, respectively; p = 0.0002). No significant difference was observed between groups for mean arterial (p = 0.2) and venous dilatations (p = 0.3), arteriovenous ratio (p = 0.09), central retinal artery equivalent (p = 0.4), and central retinal venous equivalent (p = 0.5). Conclusions: CHC may affect vessel reactivity to flicker light by increasing arteries constriction. This may reflect systemic changes in vascular functionality in subjects using CHC. Moreover, CHC should be considered as a confounding bias in studies involving DVA.
Original languageEnglish
Pages (from-to)1317 - 1322
Number of pages6
JournalArchives of Gynecology and Obstetrics
Volume294
Issue number6
DOIs
Publication statusPublished - Nov 1 2016

Fingerprint

Contraceptive Agents
Retinal Vessels
Control Groups
Retinal Artery
Vasoconstriction
Constriction
Germany
Blood Vessels
Dilatation
Arteries
Smoking
Blood Pressure
Light

Keywords

  • Combined hormonal contraceptive
  • Dynamic vessel analyzer
  • Flicker light
  • Oral contraceptive pill
  • Retinal vessel analysis
  • Static vessel analysis

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Rabiolo, A., Corvi, F., Monteduro, D., Benatti, L., Cicinelli, M. V., Fogliato, G., ... Bandello, F. (2016). Impact of combined hormonal contraceptives on vessels functionality. Archives of Gynecology and Obstetrics, 294(6), 1317 - 1322. https://doi.org/10.1007/s00404-016-4170-2

Impact of combined hormonal contraceptives on vessels functionality. / Rabiolo, Alessandro; Corvi, Federico; Monteduro, Davide; Benatti, Lucia; Cicinelli, Maria Vittoria; Fogliato, Giovanni; Querques, Giuseppe; Bandello, Francesco.

In: Archives of Gynecology and Obstetrics, Vol. 294, No. 6, 01.11.2016, p. 1317 - 1322.

Research output: Contribution to journalArticle

Rabiolo, A, Corvi, F, Monteduro, D, Benatti, L, Cicinelli, MV, Fogliato, G, Querques, G & Bandello, F 2016, 'Impact of combined hormonal contraceptives on vessels functionality', Archives of Gynecology and Obstetrics, vol. 294, no. 6, pp. 1317 - 1322. https://doi.org/10.1007/s00404-016-4170-2
Rabiolo A, Corvi F, Monteduro D, Benatti L, Cicinelli MV, Fogliato G et al. Impact of combined hormonal contraceptives on vessels functionality. Archives of Gynecology and Obstetrics. 2016 Nov 1;294(6):1317 - 1322. https://doi.org/10.1007/s00404-016-4170-2
Rabiolo, Alessandro ; Corvi, Federico ; Monteduro, Davide ; Benatti, Lucia ; Cicinelli, Maria Vittoria ; Fogliato, Giovanni ; Querques, Giuseppe ; Bandello, Francesco. / Impact of combined hormonal contraceptives on vessels functionality. In: Archives of Gynecology and Obstetrics. 2016 ; Vol. 294, No. 6. pp. 1317 - 1322.
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