Impatto dei polimorfismi genetici del CYP3A sui livelli plasmatici di carbamazepina

M. Viana; L. Magliulo; M. Mula; M. G. Scordo; C. Varrasi; S. Fallarini; R. Cantello; M. L. Dahl; G. Lombardi; F. Monaco

Impatto dei polimorfismi genetici del CYP3A sui livelli plasmatici di carbamazepina

Translated title of the contribution: Impact of CYP3A polymorphism on carbamazepine plasmatic levels

M. Viana, L. Magliulo, M. Mula, M. G. Scordo, C. Varrasi, S. Fallarini, R. Cantello, M. L. Dahl, G. Lombardi, F. Monaco

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

Carbamazepine (CBZ) is the antiepileptic drug of choice for partial and tonic-clonic seizure. CBZ is metabolized by the cytochrome P450 (CYP) system, particularly the isoforms CYP3A4 and CYP3A5. A number of allelic variants have been described for CYP3A4 and CYP3A5 potentially affecting the expression/activity of the enzymes with influences on drug metabolism. In order to evaluate the impact of CYP3A polymorphisms on CBZ plasma levels, 29 epileptic patients in CBZ therapy at steady-state were genotyped for CYP3A4 (*1B, *3, *4) e and CYP3A5 (*2,*3,*6) and the CBZ plasma levels measured.

Translated title of the contribution	Impact of CYP3A polymorphism on carbamazepine plasmatic levels
Original language	Italian
Pages (from-to)	205-207
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	140
Publication status	Published - Apr 2010

ASJC Scopus subject areas

Clinical Neurology

Cite this

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title = "Impatto dei polimorfismi genetici del CYP3A sui livelli plasmatici di carbamazepina",

abstract = "Carbamazepine (CBZ) is the antiepileptic drug of choice for partial and tonic-clonic seizure. CBZ is metabolized by the cytochrome P450 (CYP) system, particularly the isoforms CYP3A4 and CYP3A5. A number of allelic variants have been described for CYP3A4 and CYP3A5 potentially affecting the expression/activity of the enzymes with influences on drug metabolism. In order to evaluate the impact of CYP3A polymorphisms on CBZ plasma levels, 29 epileptic patients in CBZ therapy at steady-state were genotyped for CYP3A4 (*1B, *3, *4) e and CYP3A5 (*2,*3,*6) and the CBZ plasma levels measured.",

keywords = "Carbamazepine, CYP3A, Plasma levels, Polymorphism",

author = "M. Viana and L. Magliulo and M. Mula and Scordo, {M. G.} and C. Varrasi and S. Fallarini and R. Cantello and Dahl, {M. L.} and G. Lombardi and F. Monaco",

year = "2010",

month = apr,

language = "Italian",

pages = "205--207",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

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publisher = "Lega Italiana contro l'Epilessia",

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TY - JOUR

T1 - Impatto dei polimorfismi genetici del CYP3A sui livelli plasmatici di carbamazepina

AU - Viana, M.

AU - Magliulo, L.

AU - Mula, M.

AU - Scordo, M. G.

AU - Varrasi, C.

AU - Fallarini, S.

AU - Cantello, R.

AU - Dahl, M. L.

AU - Lombardi, G.

AU - Monaco, F.

PY - 2010/4

Y1 - 2010/4

N2 - Carbamazepine (CBZ) is the antiepileptic drug of choice for partial and tonic-clonic seizure. CBZ is metabolized by the cytochrome P450 (CYP) system, particularly the isoforms CYP3A4 and CYP3A5. A number of allelic variants have been described for CYP3A4 and CYP3A5 potentially affecting the expression/activity of the enzymes with influences on drug metabolism. In order to evaluate the impact of CYP3A polymorphisms on CBZ plasma levels, 29 epileptic patients in CBZ therapy at steady-state were genotyped for CYP3A4 (*1B, *3, *4) e and CYP3A5 (*2,*3,*6) and the CBZ plasma levels measured.

AB - Carbamazepine (CBZ) is the antiepileptic drug of choice for partial and tonic-clonic seizure. CBZ is metabolized by the cytochrome P450 (CYP) system, particularly the isoforms CYP3A4 and CYP3A5. A number of allelic variants have been described for CYP3A4 and CYP3A5 potentially affecting the expression/activity of the enzymes with influences on drug metabolism. In order to evaluate the impact of CYP3A polymorphisms on CBZ plasma levels, 29 epileptic patients in CBZ therapy at steady-state were genotyped for CYP3A4 (*1B, *3, *4) e and CYP3A5 (*2,*3,*6) and the CBZ plasma levels measured.

KW - Carbamazepine

KW - CYP3A

KW - Plasma levels

KW - Polymorphism

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M3 - Articolo

AN - SCOPUS:77953109770

SP - 205

EP - 207

JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

SN - 0394-560X

IS - 140

ER -

Impatto dei polimorfismi genetici del CYP3A sui livelli plasmatici di carbamazepina

Abstract

ASJC Scopus subject areas

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