Impact of diabetes on clinical outcome among elderly patients with acute coronary syndrome treated with percutaneous coronary intervention: insights from the ELDERLY ACS 2 trial: Journal of cardiovascular medicine (Hagerstown, Md.)

G. De Luca, M. Verdoia, S. Savonitto, L. Piatti, D. Grosseto, N. Morici, I. Bossi, P. Sganzerla, G. Tortorella, M. Cacucci, E. Murena, A. Toso, S. Bongioanni, A. Ravera, E. Corrada, M. Mariani, L. Di Ascenzo, A.S. Petronio, C. Cavallini, G. VitrellaR. Antonicelli, R. Rogacka, S. De Servi, Elderly ACS 2 Investigators

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Despite recent improvements in percutaneous coronary revascularization and antithrombotic therapies for the treatment of acute coronary syndromes, the outcome is still unsatisfactory in high-risk patients, such as the elderly and patients with diabetes. The aim of the current study was to investigate the prognostic impact of diabetes on clinical outcome among patients included in the Elderly-ACS 2 trial, a randomized, open-label, blinded endpoint study carried out at 32 centers in Italy. METHODS: Our population is represented by 1443 patients included in the Elderly-ACS 2 trial. Diabetes was defined as known history of diabetes at admission. The primary endpoint of this analysis was cardiovascular mortality, while secondary endpoints were all-cause death, recurrent myocardial infarction, Bleeding Academic Research Consortium type 2 or 3 bleeding, and rehospitalization for cardiovascular event or stent thrombosis within 12 months after index admission. RESULTS: Diabetes was present in 419 (29%) out of 1443 patients. Diabetic status was significantly associated with major cardiovascular risk factors and history of previous coronary disease, presentation with non-ST segment elevation myocardial infarction (P = 0.01) more extensive coronary disease (P = 0.02), more advanced Killip class at presentation (P = 0.003), use at admission of statins (P = 0.004) and diuretics at discharge (P 
Original languageEnglish
Pages (from-to)453-459
Number of pages7
JournalJ Cardiovasc Med (Hagerstown)
Volume21
Issue number6
DOIs
Publication statusPublished - 2020

Keywords

  • acute coronary syndrome
  • adverse event
  • age
  • aged
  • bleeding
  • clinical trial
  • comorbidity
  • controlled study
  • coronary artery thrombosis
  • devices
  • diabetes mellitus
  • diagnostic imaging
  • female
  • health status
  • human
  • Italy
  • male
  • mortality
  • multicenter study
  • non ST segment elevation myocardial infarction
  • percutaneous coronary intervention
  • randomized controlled trial
  • recurrent disease
  • risk assessment
  • risk factor
  • ST segment elevation myocardial infarction
  • stent
  • time factor
  • treatment outcome
  • very elderly
  • Acute Coronary Syndrome
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Comorbidity
  • Coronary Thrombosis
  • Diabetes Mellitus
  • Female
  • Health Status
  • Hemorrhage
  • Humans
  • Male
  • Non-ST Elevated Myocardial Infarction
  • Percutaneous Coronary Intervention
  • Recurrence
  • Risk Assessment
  • Risk Factors
  • ST Elevation Myocardial Infarction
  • Stents
  • Time Factors
  • Treatment Outcome

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