Impact of diabetes, patient age, and gender on the 30-day incidence of stroke and death in patients undergoing carotid artery stenting with embolus protection: A post-hoc subanalysis of a prospective multicenter registry

Michael Schlüter, Bernhard Reimers, Fausto Castriota, Thilo Tübler, Carlo Cernetti, Alberto Cremonesi, Jürgen Berger, Antonio Colombo, Joachim Schofer

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To assess the impact of diabetes, patient age, and gender on major periprocedural (30-day) complications (major and minor strokes, all-cause deaths) following carotid artery stenting (CAS). Methods: An exploratory analysis was performed of 695 patients (516 men; mean age 69.9±8.4 years) enrolled consecutively between September 1999 and September 2002 in a multicenter Italian/German registry of routine CAS using cerebral protection devices. There were 535 nondiabetic patients and 160 diabetic patients in the analysis. Results: Logistic regression analysis revealed that diabetes and age, but not gender, impacted the cumulative 30-day incidence of any stroke and death (OR 2.1, 95% CI 1.0 to 4.8, p=0.068 and OR 1.06, 95% CI 1.01 to 1.12, p=0.031, respectively), as well as the 30-day incidence of major strokes and deaths (OR 5.9, 95% CI 1.6 to 21.8, p=0.007 and OR 1.13, 95% CI 1.02 to 1.25, p=0.018, respectively). According to receiver-operating characteristic analysis, age had no discriminatory power to predict complications in nondiabetic patients, but an age of 75 years was identified as the optimal cut point to predict complications in diabetic patients. Compared with nondiabetic patients, diabetics ≥75 years had a 4.3 greater risk of experiencing any stroke or death (95% CI 1.3 to 12.3, p=0.016) and a 12.0 greater risk of a major stroke or death (95% CI 2.1 to 66.5, p=0.005). Diabetics

Original languageEnglish
Pages (from-to)271-278
Number of pages8
JournalJournal of Endovascular Therapy
Volume14
Issue number3
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Age
  • Angioplasty
  • Carotid arteries
  • Diabetes mellitus
  • Gender
  • Stent
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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