Abstract
Purpose: To assess the impact of diabetes, patient age, and gender on major periprocedural (30-day) complications (major and minor strokes, all-cause deaths) following carotid artery stenting (CAS). Methods: An exploratory analysis was performed of 695 patients (516 men; mean age 69.9±8.4 years) enrolled consecutively between September 1999 and September 2002 in a multicenter Italian/German registry of routine CAS using cerebral protection devices. There were 535 nondiabetic patients and 160 diabetic patients in the analysis. Results: Logistic regression analysis revealed that diabetes and age, but not gender, impacted the cumulative 30-day incidence of any stroke and death (OR 2.1, 95% CI 1.0 to 4.8, p=0.068 and OR 1.06, 95% CI 1.01 to 1.12, p=0.031, respectively), as well as the 30-day incidence of major strokes and deaths (OR 5.9, 95% CI 1.6 to 21.8, p=0.007 and OR 1.13, 95% CI 1.02 to 1.25, p=0.018, respectively). According to receiver-operating characteristic analysis, age had no discriminatory power to predict complications in nondiabetic patients, but an age of 75 years was identified as the optimal cut point to predict complications in diabetic patients. Compared with nondiabetic patients, diabetics ≥75 years had a 4.3 greater risk of experiencing any stroke or death (95% CI 1.3 to 12.3, p=0.016) and a 12.0 greater risk of a major stroke or death (95% CI 2.1 to 66.5, p=0.005). Diabetics
| Original language | English |
|---|---|
| Pages (from-to) | 271-278 |
| Number of pages | 8 |
| Journal | Journal of Endovascular Therapy |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2007 |
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Keywords
- Age
- Angioplasty
- Carotid arteries
- Diabetes mellitus
- Gender
- Stent
- Stroke
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Impact of diabetes, patient age, and gender on the 30-day incidence of stroke and death in patients undergoing carotid artery stenting with embolus protection : A post-hoc subanalysis of a prospective multicenter registry. / Schlüter, Michael; Reimers, Bernhard; Castriota, Fausto; Tübler, Thilo; Cernetti, Carlo; Cremonesi, Alberto; Berger, Jürgen; Colombo, Antonio; Schofer, Joachim.
In: Journal of Endovascular Therapy, Vol. 14, No. 3, 06.2007, p. 271-278.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of diabetes, patient age, and gender on the 30-day incidence of stroke and death in patients undergoing carotid artery stenting with embolus protection
T2 - A post-hoc subanalysis of a prospective multicenter registry
AU - Schlüter, Michael
AU - Reimers, Bernhard
AU - Castriota, Fausto
AU - Tübler, Thilo
AU - Cernetti, Carlo
AU - Cremonesi, Alberto
AU - Berger, Jürgen
AU - Colombo, Antonio
AU - Schofer, Joachim
PY - 2007/6
Y1 - 2007/6
N2 - Purpose: To assess the impact of diabetes, patient age, and gender on major periprocedural (30-day) complications (major and minor strokes, all-cause deaths) following carotid artery stenting (CAS). Methods: An exploratory analysis was performed of 695 patients (516 men; mean age 69.9±8.4 years) enrolled consecutively between September 1999 and September 2002 in a multicenter Italian/German registry of routine CAS using cerebral protection devices. There were 535 nondiabetic patients and 160 diabetic patients in the analysis. Results: Logistic regression analysis revealed that diabetes and age, but not gender, impacted the cumulative 30-day incidence of any stroke and death (OR 2.1, 95% CI 1.0 to 4.8, p=0.068 and OR 1.06, 95% CI 1.01 to 1.12, p=0.031, respectively), as well as the 30-day incidence of major strokes and deaths (OR 5.9, 95% CI 1.6 to 21.8, p=0.007 and OR 1.13, 95% CI 1.02 to 1.25, p=0.018, respectively). According to receiver-operating characteristic analysis, age had no discriminatory power to predict complications in nondiabetic patients, but an age of 75 years was identified as the optimal cut point to predict complications in diabetic patients. Compared with nondiabetic patients, diabetics ≥75 years had a 4.3 greater risk of experiencing any stroke or death (95% CI 1.3 to 12.3, p=0.016) and a 12.0 greater risk of a major stroke or death (95% CI 2.1 to 66.5, p=0.005). Diabetics
AB - Purpose: To assess the impact of diabetes, patient age, and gender on major periprocedural (30-day) complications (major and minor strokes, all-cause deaths) following carotid artery stenting (CAS). Methods: An exploratory analysis was performed of 695 patients (516 men; mean age 69.9±8.4 years) enrolled consecutively between September 1999 and September 2002 in a multicenter Italian/German registry of routine CAS using cerebral protection devices. There were 535 nondiabetic patients and 160 diabetic patients in the analysis. Results: Logistic regression analysis revealed that diabetes and age, but not gender, impacted the cumulative 30-day incidence of any stroke and death (OR 2.1, 95% CI 1.0 to 4.8, p=0.068 and OR 1.06, 95% CI 1.01 to 1.12, p=0.031, respectively), as well as the 30-day incidence of major strokes and deaths (OR 5.9, 95% CI 1.6 to 21.8, p=0.007 and OR 1.13, 95% CI 1.02 to 1.25, p=0.018, respectively). According to receiver-operating characteristic analysis, age had no discriminatory power to predict complications in nondiabetic patients, but an age of 75 years was identified as the optimal cut point to predict complications in diabetic patients. Compared with nondiabetic patients, diabetics ≥75 years had a 4.3 greater risk of experiencing any stroke or death (95% CI 1.3 to 12.3, p=0.016) and a 12.0 greater risk of a major stroke or death (95% CI 2.1 to 66.5, p=0.005). Diabetics
KW - Age
KW - Angioplasty
KW - Carotid arteries
KW - Diabetes mellitus
KW - Gender
KW - Stent
KW - Stroke
UR - http://www.scopus.com/inward/record.url?scp=34447320214&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447320214&partnerID=8YFLogxK
U2 - 10.1583/06-2036.1
DO - 10.1583/06-2036.1
M3 - Article
C2 - 17723014
AN - SCOPUS:34447320214
VL - 14
SP - 271
EP - 278
JO - Journal of Endovascular Therapy
JF - Journal of Endovascular Therapy
SN - 1526-6028
IS - 3
ER -