Impact of dietary fats on brain functions

Rosanna Chianese, Roberto Coccurello, Andrea Viggiano, Marika Scafuro, Marco Fiore, Giangennaro Coppola, Francesca Felicia Operto, Silvia Fasano, Sophie Layé, Riccardo Pierantoni, Rosaria Meccariello

Research output: Contribution to journalReview articlepeer-review


Background: Adequate dietary intake and nutritional status have important effects on brain functions and on brain health. Energy intake and specific nutrients excess or deficiency from diet differently affect cognitive processes, emotions, behaviour, neuroendocrine functions and synaptic plasticity with possible protective or detrimental effects on neuronal physiology. Lipids, in particular, play structural and functional roles in neurons. Here the importance of dietary fats and the need to understand the brain mechanisms activated by peripheral and central metabolic sensors. Thus, the manipulation of lifestyle factors such as dietary interventions may represent a successful therapeutic approach to maintain and preserve brain health along lifespan. Methods: This review aims at summarizing the impact of dietary fats on brain functions. Results: Starting from fat consumption, nutrient sensing and food-related reward, the impact of gut-brain communications will be discussed in brain health and disease. A specific focus will be on the impact of fats on the molecular pathways within the hypothalamus involved in the control of reproduction via the expression and the release of Gonadotropin-Releasing Hormone. Lastly, the effects of specific lipid classes such as polyunsaturated fatty acids and of the "fattest" of all diets, commonly known as "ketogenic diets", on brain functions will also be discussed. Conclusion: Despite the knowledge of the molecular mechanisms is still a work in progress, the clinical relevance of the manipulation of dietary fats is well acknowledged and such manipulations are in fact currently in use for the treatment of brain diseases.

Original languageEnglish
Pages (from-to)1059-1085
Number of pages27
JournalCurrent Neuropharmacology
Issue number7
Publication statusPublished - Jan 1 2018


  • Diet
  • Endocannabinoids
  • Epilepsy
  • Fat
  • Ghrelin
  • GnRH
  • Hypothalamus
  • Ketogenic diets
  • Kisspeptin
  • Leptin
  • Metabolic sensors
  • Microbiota
  • Neuroprotection
  • Nutrient sensing
  • PUFAs
  • Reproduction

ASJC Scopus subject areas

  • Pharmacology
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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