Impact of different treatment approaches on pregnancy outcomes in 99 women treated for Hodgkin lymphoma

Vitaliana De Sanctis, Francesco Romeo Filippone, Marco Alfò, Roberta Muni, Elena Cavalieri, Alessandro Pulsoni, Giorgia Annechini, Maurizio Valeriani, Mattia Falchetto Osti, Giuseppe Minniti, Riccardo Maurizi Enrici

Research output: Contribution to journalArticlepeer-review


Purpose: The aim of this study was to evaluate the pregnancy outcomes in women with Hodgkin lymphoma (HL) diagnosis, treated between 1972 and 1999 at Department of Radiotherapy and Hematology of University "Sapienza" of Roma. Methods and Materials: We retrospectively studied 99 female patients that conceived after treatment for HL. Fifty-nine (59%) were treated with chemotherapy and radiotherapy, 32 (32%) with radiotherapy alone as supradiaphragmatic or as infradiaphragmatic and 8 (8%) patients with chemotherapy alone. Results: Ninety-nine patients reported 145 pregnancies. We observed 132 deliveries (2 of them twin births) after a median of 55 months (range, 14-278 months) from the end of therapy. Twelve women (12%) experienced 13 miscarriages after a median of 50 months (range, 13-120) from the end of therapy. We recorded 9/132 (7%) premature births and 3/134 babies (2%) were underweight at the time of birth. We recorded 2 cases of congenital malformations. No statistical differences were recorded when adverse pregnancy outcomes were analyzed with respect to chemotherapy alone, radiotherapy alone, or combined therapy. Conclusions: No significant associations between pregnancy outcomes and therapeutic approaches were found. In particular, the infradiaphragmatic radiotherapy showed no statistical association with miscarriages, premature birth, and low birth weight at term when compared with other therapeutic approaches.

Original languageEnglish
Pages (from-to)755-761
Number of pages7
JournalInternational Journal of Radiation Oncology Biology Physics
Issue number3
Publication statusPublished - Nov 1 2012


  • Chemoradiotherapy
  • Chemotherapy
  • Hodgkin lymphoma
  • Pregnancy outcome
  • Radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation
  • Cancer Research


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