TY - JOUR
T1 - Impact of disease duration and cardiovascular dysautonomia on hypertension in Parkinson's disease
AU - Vetrano, Davide Liborio
AU - Pisciotta, Maria S.
AU - Brandi, Vincenzo
AU - Lo Monaco, Maria R.
AU - Laudisio, Alice
AU - Onder, Graziano
AU - Fusco, Domenico
AU - L'Angiocola, Paolo D.
AU - Bentivoglio, Anna R.
AU - Bernabei, Roberto
AU - Zuccalà, Giuseppe
PY - 2016/11/2
Y1 - 2016/11/2
N2 - The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4±7.6 years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.86-0.98) but not by ambulatory monitoring (OR, 0.94; 95% CI, 0.81-1.01). Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease. In conclusion, ambulatory BP monitoring improves the detection of hypertension by 15% in PD, compared with office evaluation. The likelihood of having hypertension does not decrease during the PD course; rather, BP pattern shifts towards nocturnal hypertension.
AB - The authors evaluated the association of Parkinson's disease (PD) duration with hypertension, assessed by office measurements and 24-hour (ambulatory) monitoring, in 167 patients. Hypertension was evaluated through both office and ambulatory blood pressure (BP) measurements. Among participants (mean age 73.4±7.6 years; 35% women), the prevalence of hypertension was 60% and 69% according to office and ambulatory BP measurements, respectively (Cohen's k=0.61; P<.001). PD duration was inversely associated with hypertension as diagnosed by office measurements (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.86-0.98) but not by ambulatory monitoring (OR, 0.94; 95% CI, 0.81-1.01). Ambulatory BP patterns showed higher nocturnal BP among patients with long-lasting disease. In conclusion, ambulatory BP monitoring improves the detection of hypertension by 15% in PD, compared with office evaluation. The likelihood of having hypertension does not decrease during the PD course; rather, BP pattern shifts towards nocturnal hypertension.
KW - Ambulatory blood pressure monitoring
KW - Dysautonomia
KW - Hypertension
KW - Non-motor symptoms
KW - Parkinson′s disease
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UR - http://www.scopus.com/inward/citedby.url?scp=84996671234&partnerID=8YFLogxK
U2 - 10.1111/jch.12938
DO - 10.1111/jch.12938
M3 - Article
AN - SCOPUS:84996671234
JO - Journal of the CardioMetabolic Syndrome
JF - Journal of the CardioMetabolic Syndrome
SN - 1524-6175
ER -