Impact of Educational Interventions on Psychological Distress During Allogeneic Hematopoietic Stem Cell Transplantation: A Randomised Study

Marco Cioce, Franziska Michaela Lohmeyer, Rossana Moroni, Marinella Magini, Alessandra Giraldi, Paola Garau, Maria Carola Gifuni, Vezio Savoia, Danilo Celli, Stefano Botti, Gianpaolo Gargiulo, Francesca Bonifazi, Fabio Ciceri, Ivana Serra, Maurizio Zega, Simona Sica, Andrea Bacigalupo, Valerio De Stefano, Umberto Moscato

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Physical and psychological factors, like wrong attitudes and behaviours, can negatively influence the health outcomes of the patients receiving allogeneic hematopoietic stem cell transplantation (AHSCT). Educational interventions aiming to improve knowledge on side effects, risks, complications and preventive behaviour can reduce psychological distress, and improve quality of life (QoL). We aimed to compare a standard approach with therapeutic patient education (TPE) to analyse the impact on AHSCT patients' QoL, psychological distress and knowledge of AHSCT side effects, risks complications and preventive behaviour.

Material and methods: A prospective interventional study was conducted analysing data of 36 patients who received one of two different educational approaches, which were a standard approach (not-exposed) or TPE (exposed).

Results: In the exposed group QoL improved 14 days after transplantation (42.2 vs 25.6; p<0.03) and at time of discharge (36.6 vs 54.4; p<0.005). Anxiety and depression were better controlled in the exposed group, both at hospitalisation and discharge (anxiety: 48.1 vs 53.2; 46.4 vs 51.6. p<0.04; depression: 49 vs 55.3; 48 vs 54.3, p<0.03). Knowledge of AHSCT risks and complications improved in exposed patients, both at admission (10.1/15 vs 8/15 correct answers; p<0.01) and discharge (10.7/15 vs 8.8/15 correct answer; p<0.03).

Conclusions: The TPE for AHSCT patients improved knowledge, reduced anxiety and depression, which consequently increasing QoL. Therefore, we recommend our approach to further engage patients in the treatment plan, which should specifically take place prior to AHSCT initiation.

Original languageEnglish
Article numbere2020067
JournalMediterranean Journal of Hematology and Infectious Diseases
Volume12
Issue number1
DOIs
Publication statusPublished - 2020

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