Impact of estrogen and progesterone receptor expression on the clinical and molecular features of papillary thyroid cancer

Guia Vannucchi, Simone De Leo, Michela Perrino, Stefania Rossi, Delfina Tosi, Valentina Cirello, Carla Colombo, Gaetano Bulfamante, Leonardo Vicentini, Laura Fugazzola

Research output: Contribution to journalArticlepeer-review


Background: Thyroid cancer is highly prevalent in women during the fertile age, which suggests a possible impact of hormonal and reproductive factors. Methods: We studied the expression of estrogen receptor α (ERα or ESR1) and progesterone receptor (PR or PGR) in 182 female and male patients with papillary thyroid cancer and correlated it to clinical and molecular features. Results: ERα and PR expression was found in 66.5 and 75.8% of patients respectively and was significantly correlated with larger tumor size and with a non-incidental diagnosis. Moreover, a trend toward a higher prevalence of local metastases was observed in ER- and PR-expressing tumors, which possibly indicates a more aggressive behavior. Interestingly, the occurrence of the 'receptor conversion' phenomenon, which has already been reported to have a negative prognostic effect in breast cancer, was demonstrated for the first time in thyroid tumors. Indeed, almost all of the ERα-positive primary tumors analyzed had ERα-negative metastatic lymph nodes. At the genetic analyses, BRAFV600E mutation was detected in 23.2% of the tumors and had a higher prevalence in larger tumors and in those with a stronger ERα or PR staining. Conclusions: The whole of the findings reported in the present study argue for an association between ERα and PR sex hormone receptor expression and a more aggressive presentation. Although no impact on outcome was found, the evaluation of ERα and PR receptor expression could add insights into the biological behavior of tumors and could modify the follow-up, particularly in fertile women affected with persistent disease.

Original languageEnglish
Pages (from-to)29-36
Number of pages8
JournalEuropean Journal of Endocrinology
Issue number1
Publication statusPublished - Jul 1 2015

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Fingerprint Dive into the research topics of 'Impact of estrogen and progesterone receptor expression on the clinical and molecular features of papillary thyroid cancer'. Together they form a unique fingerprint.

Cite this