Impact of exacerbations in the natural course of COPD

Francesco Blasi, Stefano Aliberti, Marco Mantero

Research output: Contribution to journalArticlepeer-review


Exacerbations represent an important event in the natural history of patients with chronic obstructive pulmonary disease (COPD). They are associated with considerable physiological deterioration and increased airway inflammatory changes, and may enhance disease progression by accelerating the decline in lung function. Some patients are prone to frequent exacerbations, which are an important cause of hospital admission and readmission, and these frequent episodes may have considerable impact on quality of life, activities of daily living and mortality. Although exacerbations become more frequent and more severe as COPD progresses, the rate at which they occur appears to reflect an independent susceptibility phenotype: the "frequent exacerbator".

Original languageEnglish
Pages (from-to)84-95
Number of pages12
JournalEuropean Respiratory Monograph
Publication statusPublished - 2013


  • Chronic obstructive pulmonary disease
  • Exacerbation
  • Inflammation
  • Phenotype
  • Quality of life

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Impact of exacerbations in the natural course of COPD'. Together they form a unique fingerprint.

Cite this