Abstract
The impact of HAART on the progression of HCV related liver disease is controversial. This retrospective study compares the grading and staging of chronic viral hepatitis in HIV/HCV coinfected subjects treated or not with antiretroviral therapy (ART) including protease inibithors (PI). The liver histology of 44 HIV/HCV coinfected patients on ART for more than 12 months, 26 coinfected patients naïve for ART and 31 HCV monoinfected patients were analysed by the Ishak score. None of the multivariate models calculated to test if liver histopathology (Ishak grading or staging) between HlV/HCV coinfected patients versus HCV monoinfected or antiretroviral-treated versus untreated HIV+ subjects showed any statistical difference. No significant difference between grading and staging was evidenced either in PI treated subjects versus patients on ART without PI.
| Original language | English |
|---|---|
| Pages (from-to) | 195-197 |
| Number of pages | 3 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 17 |
| Issue number | 2 |
| Publication status | Published - Apr 2003 |
Keywords
- Chronic hepatitis C
- HAART
- Liver histology
ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
- Endocrinology
- Physiology
- Immunology
- Medicine (miscellaneous)
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)