Impact of heart failure on the clinical course and outcomes of patients hospitalized for COVID-19. Results of the Cardio-COVID-Italy multicentre study

Daniela Tomasoni, Riccardo M. Inciardi, Carlo M. Lombardi, Chiara Tedino, Piergiuseppe Agostoni, Pietro Ameri, Lucia Barbieri, Antonio Bellasi, Rita Camporotondo, Claudia Canale, Valentina Carubelli, Stefano Carugo, Francesco Catagnano, Laura A. Dalla Vecchia, Gian Battista Danzi, Mattia Di Pasquale, Margherita Gaudenzi, Stefano Giovinazzo, Massimiliano Gnecchi, Annamaria IorioMaria Teresa La Rovere, Sergio Leonardi, Gloria Maccagni, Massimo Mapelli, Davide Margonato, Marco Merlo, Luca Monzo, Andrea Mortara, Vincenzo Nuzzi, Massimo Piepoli, Italo Porto, Andrea Pozzi, Filippo Sarullo, Gianfranco Sinagra, Maurizio Volterrani, Gregorio Zaccone, Marco Guazzi, Michele Senni, Marco Metra

Research output: Contribution to journalArticlepeer-review

Abstract

Abstract Aims To assess the prognostic value of a history of heart failure (HF) in patients with coronavirus disease 2019 (COVID-19). Methods and results We enrolled 692 consecutive patients admitted for COVID-19 in 13 Italian cardiology centres between 1 March and 9 April 2020. Mean age was 67.4 ±?13.2?years, 69.5% of patients were males, 90 (13.0%) had a history of HF, median hospitalization length was 14?days (interquartile range 9?24). In-hospital death occurred in 37 of 90 patients (41.1%) with HF history vs. 126 of those with no HF history (20.9%). The increased risk of death associated with HF history remained significant after adjustment for clinical variables related to COVID-19 and HF severity, including comorbidities, oxygen saturation, lymphocyte count and plasma troponin [adjusted hazard ratio (HR) for death: 2.25; 95% confidence interval (CI) 1.26?4.02; P =?0.006 at multivariable Cox regression model including 404 patients]. Patients with a history of HF also had more in-hospital complications including acute HF (33.3% vs. 5.1%, P 
Original languageEnglish
Pages (from-to)2238-2247
Number of pages10
JournalEuropean Journal of Heart Failure
Volume22
Issue number12
DOIs
Publication statusPublished - 2020

Keywords

  • COVID-19
  • SARS-CoV-2 Infection
  • Heart failure
  • Outcome

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