Impact of heparin or non-heparin coated circuits on platelet function in pediatric cardiac surgery

Chiara Giorni, Chiara Pezzella, Mirela Bojan, Zaccaria Ricci, Philippe Pouard, Olivier Raisky, Laurent Tourneur, Ondina La Salvia, Isabella Favia, Delphine Borgel, Paola Cogo, Adriano Carotti, Dominique Lasne

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Extracorporeal circuit coating has been shown to improve coagulation derangements during pediatric cardiopulmonary bypass (CPB). The aim of this study was to compare platelet function and hemostasis activation in pediatric cardiac surgery conducted with non-heparin coating (Balance®) versus heparin-based coating (Carmeda®) circuits.

METHODS: A prospective, randomized, double-center trial was conducted in children older than one month undergoing congenital heart disease (CHD) treatment. Blood samples were collected at baseline (T0), 15 minutes after the start of CPB (T1), and 15 minutes (T2) and 1 hour after the conclusion of CPB (T3). The primary endpoint of the study was to detect potential differences in Beta-thromboglobulin levels between the two groups at T2. Other coagulation and platelet function parameters were analyzed as secondary endpoints.

RESULTS: Beta-thromboglobulin increased significantly at T2 in both groups. However, there was no significant difference between the groups across all time points. There was no difference in the secondary endpoints between the groups.

CONCLUSIONS: The two circuits showed similar biological effects on platelet function and coagulation. This observation may be useful in optimizing the conduct of CPB and in rationalizing its cost for the treatment of CHD.

Original languageEnglish
JournalAnnals of Thoracic Surgery
DOIs
Publication statusE-pub ahead of print - Nov 2 2018

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Cardiopulmonary Bypass
Thoracic Surgery
Heparin
Blood Platelets
Pediatrics
beta-Thromboglobulin
Heart Diseases
Hemostasis
Health Care Costs
Therapeutics

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Impact of heparin or non-heparin coated circuits on platelet function in pediatric cardiac surgery. / Giorni, Chiara; Pezzella, Chiara; Bojan, Mirela; Ricci, Zaccaria; Pouard, Philippe; Raisky, Olivier; Tourneur, Laurent; La Salvia, Ondina; Favia, Isabella; Borgel, Delphine; Cogo, Paola; Carotti, Adriano; Lasne, Dominique.

In: Annals of Thoracic Surgery, 02.11.2018.

Research output: Contribution to journalArticle

Giorni, Chiara ; Pezzella, Chiara ; Bojan, Mirela ; Ricci, Zaccaria ; Pouard, Philippe ; Raisky, Olivier ; Tourneur, Laurent ; La Salvia, Ondina ; Favia, Isabella ; Borgel, Delphine ; Cogo, Paola ; Carotti, Adriano ; Lasne, Dominique. / Impact of heparin or non-heparin coated circuits on platelet function in pediatric cardiac surgery. In: Annals of Thoracic Surgery. 2018.
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abstract = "BACKGROUND: Extracorporeal circuit coating has been shown to improve coagulation derangements during pediatric cardiopulmonary bypass (CPB). The aim of this study was to compare platelet function and hemostasis activation in pediatric cardiac surgery conducted with non-heparin coating (Balance{\circledR}) versus heparin-based coating (Carmeda{\circledR}) circuits.METHODS: A prospective, randomized, double-center trial was conducted in children older than one month undergoing congenital heart disease (CHD) treatment. Blood samples were collected at baseline (T0), 15 minutes after the start of CPB (T1), and 15 minutes (T2) and 1 hour after the conclusion of CPB (T3). The primary endpoint of the study was to detect potential differences in Beta-thromboglobulin levels between the two groups at T2. Other coagulation and platelet function parameters were analyzed as secondary endpoints.RESULTS: Beta-thromboglobulin increased significantly at T2 in both groups. However, there was no significant difference between the groups across all time points. There was no difference in the secondary endpoints between the groups.CONCLUSIONS: The two circuits showed similar biological effects on platelet function and coagulation. This observation may be useful in optimizing the conduct of CPB and in rationalizing its cost for the treatment of CHD.",
author = "Chiara Giorni and Chiara Pezzella and Mirela Bojan and Zaccaria Ricci and Philippe Pouard and Olivier Raisky and Laurent Tourneur and {La Salvia}, Ondina and Isabella Favia and Delphine Borgel and Paola Cogo and Adriano Carotti and Dominique Lasne",
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T1 - Impact of heparin or non-heparin coated circuits on platelet function in pediatric cardiac surgery

AU - Giorni, Chiara

AU - Pezzella, Chiara

AU - Bojan, Mirela

AU - Ricci, Zaccaria

AU - Pouard, Philippe

AU - Raisky, Olivier

AU - Tourneur, Laurent

AU - La Salvia, Ondina

AU - Favia, Isabella

AU - Borgel, Delphine

AU - Cogo, Paola

AU - Carotti, Adriano

AU - Lasne, Dominique

N1 - Copyright © 2018. Published by Elsevier Inc.

PY - 2018/11/2

Y1 - 2018/11/2

N2 - BACKGROUND: Extracorporeal circuit coating has been shown to improve coagulation derangements during pediatric cardiopulmonary bypass (CPB). The aim of this study was to compare platelet function and hemostasis activation in pediatric cardiac surgery conducted with non-heparin coating (Balance®) versus heparin-based coating (Carmeda®) circuits.METHODS: A prospective, randomized, double-center trial was conducted in children older than one month undergoing congenital heart disease (CHD) treatment. Blood samples were collected at baseline (T0), 15 minutes after the start of CPB (T1), and 15 minutes (T2) and 1 hour after the conclusion of CPB (T3). The primary endpoint of the study was to detect potential differences in Beta-thromboglobulin levels between the two groups at T2. Other coagulation and platelet function parameters were analyzed as secondary endpoints.RESULTS: Beta-thromboglobulin increased significantly at T2 in both groups. However, there was no significant difference between the groups across all time points. There was no difference in the secondary endpoints between the groups.CONCLUSIONS: The two circuits showed similar biological effects on platelet function and coagulation. This observation may be useful in optimizing the conduct of CPB and in rationalizing its cost for the treatment of CHD.

AB - BACKGROUND: Extracorporeal circuit coating has been shown to improve coagulation derangements during pediatric cardiopulmonary bypass (CPB). The aim of this study was to compare platelet function and hemostasis activation in pediatric cardiac surgery conducted with non-heparin coating (Balance®) versus heparin-based coating (Carmeda®) circuits.METHODS: A prospective, randomized, double-center trial was conducted in children older than one month undergoing congenital heart disease (CHD) treatment. Blood samples were collected at baseline (T0), 15 minutes after the start of CPB (T1), and 15 minutes (T2) and 1 hour after the conclusion of CPB (T3). The primary endpoint of the study was to detect potential differences in Beta-thromboglobulin levels between the two groups at T2. Other coagulation and platelet function parameters were analyzed as secondary endpoints.RESULTS: Beta-thromboglobulin increased significantly at T2 in both groups. However, there was no significant difference between the groups across all time points. There was no difference in the secondary endpoints between the groups.CONCLUSIONS: The two circuits showed similar biological effects on platelet function and coagulation. This observation may be useful in optimizing the conduct of CPB and in rationalizing its cost for the treatment of CHD.

U2 - 10.1016/j.athoracsur.2018.09.032

DO - 10.1016/j.athoracsur.2018.09.032

M3 - Article

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JO - Annals of Thoracic Surgery

JF - Annals of Thoracic Surgery

SN - 0003-4975

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