Impact of Histology and Tumor Grade on Clinical Outcomes Beyond 5 Years of Follow-Up in a Large Cohort of Renal Cell Carcinomas

Manuela Costantini, Maria Luana Poeta, Ruth M. Pfeiffer, Dana Hashim, Catherine L. Callahan, Steno Sentinelli, Laura Mendoza, Marco Vicari, Vincenzo Pompeo, Angela Cecilia Pesatori, Curt T. DellaValle, Giuseppe Simone, Vito Michele Fazio, Michele Gallucci, Maria Teresa Landi

Research output: Contribution to journalArticlepeer-review


Introduction: The optimal length for clinical follow-up of renal cell carcinoma (RCC) patients is unclear. We evaluated the impact of ISUP/WHO tumor grade and histological subtype on short- and long-term survival and risk of recurrence/metastasis in a large cohort of RCC patients. Patients and Methods: We studied 1679 RCC patients from a single referral center in Italy. Adjusted hazard ratios for overall survival were estimated using Cox regression models. Adjusted absolute risk of developing recurrence or metastasis was computed considering competing risks of mortality. Results: During up to 13 years of follow-up, 175 (10.4%) RCC patients died, of whom 92% beyond 5 years. Hazard ratio of grade IV clear cell carcinomas (ccRCC) was 3.82 compared to grade II. Notably, 33% of recurrences and 56% of distant metastases occurred beyond 5 years of follow-up. The estimated probabilities of recurrence/metastasis were 15% and 45% within and beyond 5 years of follow-up, respectively. After 5 years, the absolute risk of recurrences increased also for papillary renal cell carcinoma type I (35.2%) and grade I ccRCC (17%). Conclusion: After 5 years of follow-up, both risk of mortality and recurrences or metastases were high and were modified by histological types and tumor grade. These data strongly support histology- and grade-tailored surveillance strategies and long-term follow-up for RCC patients.

Original languageEnglish
Pages (from-to)e280-e285
JournalClinical Genitourinary Cancer
Issue number5
Publication statusPublished - 2021


  • Absolute risk
  • Histology
  • Recurrence
  • Renal cell carcinoma
  • Surveillance

ASJC Scopus subject areas

  • Oncology
  • Urology


Dive into the research topics of 'Impact of Histology and Tumor Grade on Clinical Outcomes Beyond 5 Years of Follow-Up in a Large Cohort of Renal Cell Carcinomas'. Together they form a unique fingerprint.

Cite this