Impact of hospitalization on modification of drug regimens: Results of the Criteria to Assess Appropriate Medication Use Among Elderly Complex Patients study

Federica Sganga, Francesco Landi, Davide L. Vetrano, Andrea Corsonello, Fabrizia Lattanzio, Roberto Bernabei, Graziano Onder

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Aim: To assess the impact of hospitalization on modification of drug burden among elderly patients. Methods: The present prospective cohort study was carried out in acute care hospitals in Italy. The difference in the number of drugs used before hospital admission and those prescribed at discharge was calculated. The prevalence of (i) any increase (1 or more drugs); and (ii) an increase >50% in the number of drugs from admission to discharge was calculated, and the factors associated with these conditions were identified. Results: The mean age of 1082 participants was 81.2±7.3 years and 606 were women (56.0%), an increase in the number of drugs (1 or more drugs) between admission and discharge was observed in 672 participants (62.1% of study sample) and an "increase >50%" was observed in 372 participants (34.3%). "Any increase" was inversely associated with age and the number of drugs used before hospitalization, and it was positively associated with length of stay and diagnoses, including chronic obstructive pulmonary disease, ischemic heart disease and diabetes. "Increase >50%" was inversely associated with female sex, the number of drugs before hospitalization, involuntary loss of weight and intact cognitive status, and was positively associated with length of stay, chronic obstructive pulmonary disease, heart failure and diabetes. Conclusions: Not only disease, but also demographic factors (age and gender) and geriatric syndromes (weight loss and cognitive status) might influence pharmacological burden. These data might be useful in order to target interventions aimed at improving drug use and reducing iatrogenic illness.

Original languageEnglish
JournalGeriatrics and Gerontology International
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

hospitalization
Hospitalization
medication
drug
Pharmaceutical Preparations
heart disease
chronic illness
Chronic Obstructive Pulmonary Disease
Weight Loss
Length of Stay
Disease
geriatrics
demographic factors
drug use
Geriatrics
Italy
Myocardial Ischemia
illness
Cohort Studies
Heart Failure

Keywords

  • Drugs
  • Elderly
  • Polypharmacy

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Gerontology
  • Health(social science)

Cite this

@article{74c4eae253b14850ad12f0f381bab48b,
title = "Impact of hospitalization on modification of drug regimens: Results of the Criteria to Assess Appropriate Medication Use Among Elderly Complex Patients study",
abstract = "Aim: To assess the impact of hospitalization on modification of drug burden among elderly patients. Methods: The present prospective cohort study was carried out in acute care hospitals in Italy. The difference in the number of drugs used before hospital admission and those prescribed at discharge was calculated. The prevalence of (i) any increase (1 or more drugs); and (ii) an increase >50{\%} in the number of drugs from admission to discharge was calculated, and the factors associated with these conditions were identified. Results: The mean age of 1082 participants was 81.2±7.3 years and 606 were women (56.0{\%}), an increase in the number of drugs (1 or more drugs) between admission and discharge was observed in 672 participants (62.1{\%} of study sample) and an {"}increase >50{\%}{"} was observed in 372 participants (34.3{\%}). {"}Any increase{"} was inversely associated with age and the number of drugs used before hospitalization, and it was positively associated with length of stay and diagnoses, including chronic obstructive pulmonary disease, ischemic heart disease and diabetes. {"}Increase >50{\%}{"} was inversely associated with female sex, the number of drugs before hospitalization, involuntary loss of weight and intact cognitive status, and was positively associated with length of stay, chronic obstructive pulmonary disease, heart failure and diabetes. Conclusions: Not only disease, but also demographic factors (age and gender) and geriatric syndromes (weight loss and cognitive status) might influence pharmacological burden. These data might be useful in order to target interventions aimed at improving drug use and reducing iatrogenic illness.",
keywords = "Drugs, Elderly, Polypharmacy",
author = "Federica Sganga and Francesco Landi and Vetrano, {Davide L.} and Andrea Corsonello and Fabrizia Lattanzio and Roberto Bernabei and Graziano Onder",
year = "2015",
doi = "10.1111/ggi.12517",
language = "English",
journal = "Geriatrics and Gerontology International",
issn = "1447-0594",
publisher = "Japan Geriatrics Society",

}

TY - JOUR

T1 - Impact of hospitalization on modification of drug regimens

T2 - Results of the Criteria to Assess Appropriate Medication Use Among Elderly Complex Patients study

AU - Sganga, Federica

AU - Landi, Francesco

AU - Vetrano, Davide L.

AU - Corsonello, Andrea

AU - Lattanzio, Fabrizia

AU - Bernabei, Roberto

AU - Onder, Graziano

PY - 2015

Y1 - 2015

N2 - Aim: To assess the impact of hospitalization on modification of drug burden among elderly patients. Methods: The present prospective cohort study was carried out in acute care hospitals in Italy. The difference in the number of drugs used before hospital admission and those prescribed at discharge was calculated. The prevalence of (i) any increase (1 or more drugs); and (ii) an increase >50% in the number of drugs from admission to discharge was calculated, and the factors associated with these conditions were identified. Results: The mean age of 1082 participants was 81.2±7.3 years and 606 were women (56.0%), an increase in the number of drugs (1 or more drugs) between admission and discharge was observed in 672 participants (62.1% of study sample) and an "increase >50%" was observed in 372 participants (34.3%). "Any increase" was inversely associated with age and the number of drugs used before hospitalization, and it was positively associated with length of stay and diagnoses, including chronic obstructive pulmonary disease, ischemic heart disease and diabetes. "Increase >50%" was inversely associated with female sex, the number of drugs before hospitalization, involuntary loss of weight and intact cognitive status, and was positively associated with length of stay, chronic obstructive pulmonary disease, heart failure and diabetes. Conclusions: Not only disease, but also demographic factors (age and gender) and geriatric syndromes (weight loss and cognitive status) might influence pharmacological burden. These data might be useful in order to target interventions aimed at improving drug use and reducing iatrogenic illness.

AB - Aim: To assess the impact of hospitalization on modification of drug burden among elderly patients. Methods: The present prospective cohort study was carried out in acute care hospitals in Italy. The difference in the number of drugs used before hospital admission and those prescribed at discharge was calculated. The prevalence of (i) any increase (1 or more drugs); and (ii) an increase >50% in the number of drugs from admission to discharge was calculated, and the factors associated with these conditions were identified. Results: The mean age of 1082 participants was 81.2±7.3 years and 606 were women (56.0%), an increase in the number of drugs (1 or more drugs) between admission and discharge was observed in 672 participants (62.1% of study sample) and an "increase >50%" was observed in 372 participants (34.3%). "Any increase" was inversely associated with age and the number of drugs used before hospitalization, and it was positively associated with length of stay and diagnoses, including chronic obstructive pulmonary disease, ischemic heart disease and diabetes. "Increase >50%" was inversely associated with female sex, the number of drugs before hospitalization, involuntary loss of weight and intact cognitive status, and was positively associated with length of stay, chronic obstructive pulmonary disease, heart failure and diabetes. Conclusions: Not only disease, but also demographic factors (age and gender) and geriatric syndromes (weight loss and cognitive status) might influence pharmacological burden. These data might be useful in order to target interventions aimed at improving drug use and reducing iatrogenic illness.

KW - Drugs

KW - Elderly

KW - Polypharmacy

UR - http://www.scopus.com/inward/record.url?scp=84930348036&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930348036&partnerID=8YFLogxK

U2 - 10.1111/ggi.12517

DO - 10.1111/ggi.12517

M3 - Article

AN - SCOPUS:84930348036

JO - Geriatrics and Gerontology International

JF - Geriatrics and Gerontology International

SN - 1447-0594

ER -