Impact of human leukocyte antigen polymorphisms in human immunodeficiency virus progression in a paediatric cohort infected with a mono-phyletic human immunodeficiency virus-1 strain

Carla Montesano, Cesira Tiziana Bonanno, Alba Grifoni, Caterina Di Sano, Paolo Palma, Guido Castelli-Gattinara, Maurizio Mattei, Giorgio Mancino, Alfredo Salerno, Vittorio Colizzi, Massimo Amicosante

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: HLA polymorphisms within the peptide binding pocket have been associated with rapid and slowprogression to AIDS, suggesting that the capability to present efficiently HIV-1 epitopes is crucial for the infection control. To minimize the effects of genetic background due to population coming from different geographic area and viral strain variability in the cohort, an analysis of all the polymorphisms associated with the HLA-A, -B and -DR alleles has been performed in a cohort of children with a monophyletic HIV-1 infection (CRF02_AG) during an outbreak in Libya. Methods: High-resolution HLA-typing has been performed in 58 children infected with a monophyletic strain of HIV-1: 26 Long-Term Non-Progressors (LTNP), 9 Slow-Progressors (SP) and 23 Fast-Progressors (FP). HLA amino acid polymorphism frequency has been compared in the in FP respect to LTNP. Results: HLA-B resulted the most interesting locus of the study; 10 positions located in B- and F-pocket for peptidebinding have been found significant after Bonferroni's correction: 11S (LTNP=7.69% FP=34.78% OR=0.156 P

Original languageEnglish
Article number1000282
JournalJournal of AIDS and Clinical Research
Volume5
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Children
  • Epitope
  • HIV-1
  • HLA
  • Peptide binding motif
  • Susceptibility

ASJC Scopus subject areas

  • Infectious Diseases
  • Dermatology
  • Immunology
  • Virology

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