Impact of human metapneumovirus in childhood: Comparison with respiratory syncytial virus and influenza viruses

Samantha Bosis, Susanna Esposito, Hubert G M Niesters, Piero Crovari, Albert D M E Osterhaus, Nicola Principi

Research output: Contribution to journalArticle

Abstract

This study evaluated the overall impact of human metapneumovirus (hMPV) infection in 1,505 children and their households, and compared it with infections due to respiratory syncytial virus (RSV) and influenza viruses. Nasopharyngeal swabs were used at enrollment to collect specimens for the detection of hMPV, RSV, and influenza virus RNA by reverse-transcriptase polymerase chain reaction (RT-PCR). hMPV was detected in 42 children (2.8%), RSV in 143 (9.5%; P <0.0001 vs. hMPV), and influenza viruses in 230 (15.3%; P<0.0001 vs. hMPV). Of the 42 hMPV-positive samples, one was also positive for RSV and six for influenza viruses, for a co-infection rate of 16.7%. Clinically, hMPV was identified only in patients with acute respiratory infection, whereas RSV and influenza viruses were also detected in patients with different clinical manifestations. Symptoms with statistically significant different proportions at presentation were fever (more frequent in the hMPV- and influenza-positive children) and wheezing with bronchiolitis or asthma exacerbation (more frequent among hMPV- and RSV-positive cases). The households of the hMPV- and the influenza-positive children had significantly more illnesses, needed significantly more medical visits, received more antipyretics, and missed significantly more work or school days than those of the RSV-positive children. Results show that hMPV is an emerging cause of acute respiratory infection in childhood, and may have a significant clinical and socioeconomic impact on children and their families.

Original languageEnglish
Pages (from-to)101-104
Number of pages4
JournalJournal of Medical Virology
Volume75
Issue number1
DOIs
Publication statusPublished - Jan 2005

Fingerprint

Metapneumovirus
Respiratory Syncytial Viruses
Orthomyxoviridae
Human respiratory syncytial virus
Human Influenza
Respiratory Tract Infections
Antipyretics
Bronchiolitis
RNA-Directed DNA Polymerase
Respiratory Sounds
Infection
Reverse Transcriptase Polymerase Chain Reaction
Coinfection
Fever

Keywords

  • Acute respiratory infection
  • Children
  • Human metapneumovirus
  • Influenza viruses
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Virology

Cite this

Impact of human metapneumovirus in childhood : Comparison with respiratory syncytial virus and influenza viruses. / Bosis, Samantha; Esposito, Susanna; Niesters, Hubert G M; Crovari, Piero; Osterhaus, Albert D M E; Principi, Nicola.

In: Journal of Medical Virology, Vol. 75, No. 1, 01.2005, p. 101-104.

Research output: Contribution to journalArticle

Bosis, Samantha ; Esposito, Susanna ; Niesters, Hubert G M ; Crovari, Piero ; Osterhaus, Albert D M E ; Principi, Nicola. / Impact of human metapneumovirus in childhood : Comparison with respiratory syncytial virus and influenza viruses. In: Journal of Medical Virology. 2005 ; Vol. 75, No. 1. pp. 101-104.
@article{7f921e84124546a59c7094ab7c5d5aad,
title = "Impact of human metapneumovirus in childhood: Comparison with respiratory syncytial virus and influenza viruses",
abstract = "This study evaluated the overall impact of human metapneumovirus (hMPV) infection in 1,505 children and their households, and compared it with infections due to respiratory syncytial virus (RSV) and influenza viruses. Nasopharyngeal swabs were used at enrollment to collect specimens for the detection of hMPV, RSV, and influenza virus RNA by reverse-transcriptase polymerase chain reaction (RT-PCR). hMPV was detected in 42 children (2.8{\%}), RSV in 143 (9.5{\%}; P <0.0001 vs. hMPV), and influenza viruses in 230 (15.3{\%}; P<0.0001 vs. hMPV). Of the 42 hMPV-positive samples, one was also positive for RSV and six for influenza viruses, for a co-infection rate of 16.7{\%}. Clinically, hMPV was identified only in patients with acute respiratory infection, whereas RSV and influenza viruses were also detected in patients with different clinical manifestations. Symptoms with statistically significant different proportions at presentation were fever (more frequent in the hMPV- and influenza-positive children) and wheezing with bronchiolitis or asthma exacerbation (more frequent among hMPV- and RSV-positive cases). The households of the hMPV- and the influenza-positive children had significantly more illnesses, needed significantly more medical visits, received more antipyretics, and missed significantly more work or school days than those of the RSV-positive children. Results show that hMPV is an emerging cause of acute respiratory infection in childhood, and may have a significant clinical and socioeconomic impact on children and their families.",
keywords = "Acute respiratory infection, Children, Human metapneumovirus, Influenza viruses, Respiratory syncytial virus",
author = "Samantha Bosis and Susanna Esposito and Niesters, {Hubert G M} and Piero Crovari and Osterhaus, {Albert D M E} and Nicola Principi",
year = "2005",
month = "1",
doi = "10.1002/jmv.20243",
language = "English",
volume = "75",
pages = "101--104",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - Impact of human metapneumovirus in childhood

T2 - Comparison with respiratory syncytial virus and influenza viruses

AU - Bosis, Samantha

AU - Esposito, Susanna

AU - Niesters, Hubert G M

AU - Crovari, Piero

AU - Osterhaus, Albert D M E

AU - Principi, Nicola

PY - 2005/1

Y1 - 2005/1

N2 - This study evaluated the overall impact of human metapneumovirus (hMPV) infection in 1,505 children and their households, and compared it with infections due to respiratory syncytial virus (RSV) and influenza viruses. Nasopharyngeal swabs were used at enrollment to collect specimens for the detection of hMPV, RSV, and influenza virus RNA by reverse-transcriptase polymerase chain reaction (RT-PCR). hMPV was detected in 42 children (2.8%), RSV in 143 (9.5%; P <0.0001 vs. hMPV), and influenza viruses in 230 (15.3%; P<0.0001 vs. hMPV). Of the 42 hMPV-positive samples, one was also positive for RSV and six for influenza viruses, for a co-infection rate of 16.7%. Clinically, hMPV was identified only in patients with acute respiratory infection, whereas RSV and influenza viruses were also detected in patients with different clinical manifestations. Symptoms with statistically significant different proportions at presentation were fever (more frequent in the hMPV- and influenza-positive children) and wheezing with bronchiolitis or asthma exacerbation (more frequent among hMPV- and RSV-positive cases). The households of the hMPV- and the influenza-positive children had significantly more illnesses, needed significantly more medical visits, received more antipyretics, and missed significantly more work or school days than those of the RSV-positive children. Results show that hMPV is an emerging cause of acute respiratory infection in childhood, and may have a significant clinical and socioeconomic impact on children and their families.

AB - This study evaluated the overall impact of human metapneumovirus (hMPV) infection in 1,505 children and their households, and compared it with infections due to respiratory syncytial virus (RSV) and influenza viruses. Nasopharyngeal swabs were used at enrollment to collect specimens for the detection of hMPV, RSV, and influenza virus RNA by reverse-transcriptase polymerase chain reaction (RT-PCR). hMPV was detected in 42 children (2.8%), RSV in 143 (9.5%; P <0.0001 vs. hMPV), and influenza viruses in 230 (15.3%; P<0.0001 vs. hMPV). Of the 42 hMPV-positive samples, one was also positive for RSV and six for influenza viruses, for a co-infection rate of 16.7%. Clinically, hMPV was identified only in patients with acute respiratory infection, whereas RSV and influenza viruses were also detected in patients with different clinical manifestations. Symptoms with statistically significant different proportions at presentation were fever (more frequent in the hMPV- and influenza-positive children) and wheezing with bronchiolitis or asthma exacerbation (more frequent among hMPV- and RSV-positive cases). The households of the hMPV- and the influenza-positive children had significantly more illnesses, needed significantly more medical visits, received more antipyretics, and missed significantly more work or school days than those of the RSV-positive children. Results show that hMPV is an emerging cause of acute respiratory infection in childhood, and may have a significant clinical and socioeconomic impact on children and their families.

KW - Acute respiratory infection

KW - Children

KW - Human metapneumovirus

KW - Influenza viruses

KW - Respiratory syncytial virus

UR - http://www.scopus.com/inward/record.url?scp=9644264065&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9644264065&partnerID=8YFLogxK

U2 - 10.1002/jmv.20243

DO - 10.1002/jmv.20243

M3 - Article

C2 - 15543589

AN - SCOPUS:9644264065

VL - 75

SP - 101

EP - 104

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 1

ER -